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http://dx.doi.org/10.1016/j.jacr.2014.12.018 | DOI Listing |
Lancet Gastroenterol Hepatol
January 2025
Department of Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milan, Italy.
Background: Tamuzimod (VTX002) is a selective sphingosine 1-phosphate receptor 1 modulator in development for ulcerative colitis. We aimed to assess the safety and efficacy of tamuzimod in patients with moderately-to-severely active ulcerative colitis.
Methods: This double-blind, randomised, placebo-controlled, phase 2 induction trial was conducted at 122 centres across 15 countries in Asia, Europe, and North America.
PLoS One
January 2025
Grupo de Investigación en Biodiversidad, Zoonosis y Salud Pública (GIBCIZ), Facultad de Ciencias Químicas (FCQ), Facultad de Ingeniería Química (FIQ), Facultad de Medicina Veterinaria y Zootecnia (FMVZ), Instituto de Salud Pública y Zoonosis (CIZ), Universidad Central del Ecuador, Quito, Ecuador.
Studying the microbial communities within the gastrointestinal tract of vertebrate species can provide insights into biodiversity, disease ecology, and conservation. Currently, we have very limited understanding of the composition of endogenous microbiota in wildlife, particularly in high biodiversity tropical areas. Knowledge is limited by the logistical and ethical challenges of obtaining samples for free-living animals.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Prosthetic Dental Sciences, Jouf University, Sakaka, KSA Kingdom of Saudi Arabia.
Background And Objectives: Aim of the current study was to assess the perception, preference, and practice of endodontists and restorative dentists at different locations around the world about dental magnification instruments.
Materials And Methods: A multicenter, cross-sectional study was ethically approved from the local committee of bioethics. After thorough literature search, a questionnaire was designed and validated.
Sci Rep
January 2025
, Budapest, Hungary.
We present a methodology to develop the integrated climate change transition and physical risk assessment of industrial companies in Europe, Northern America and Australia. There is an increasingly important need for effective large-scale climate change risk assessment solutions with more governments aligning their company reporting regulations with the Task Force on Climate-related Financial Disclosures recommendations. In this paper, we measure key aspects of climate change risks of industrial firms on the globe and vice versa.
View Article and Find Full Text PDFViruses
December 2024
Faculty of Medicine, Federal University of Vale do São Francisco-UNIVASF, Petrolina 56304-917, PE, Brazil.
Arthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden of these acute febrile illnesses, but also the cardiovascular complications that are worsened by urbanization. A cross-sectional study was conducted in an Indigenous population in the Northeast Region of Brazil to explore the association between arboviral infections (dengue, chikungunya, and Zika) and cardiac biomarkers, including cardiotrophin 1, growth differentiation factor 15, lactate dehydrogenase B, fatty-acid-binding protein 3, myoglobin, N-terminal pro-B-type natriuretic peptide, cardiac troponin I, big endothelin 1, and creatine kinase-MB, along with clinical and anthropometric factors.
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