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Left Ventricular Thrombosis in Immune Checkpoint Inhibitor Myocarditis Mimicking ST-Segment Elevation Myocardial Infarction.
JACC Case Rep
November 2024
Cardiology Unit, Morgagni Pierantoni Hospital Forlì, Italy.
Article Synopsis
- A case of ventricular thrombosis linked to myocarditis from immune checkpoint inhibitors (ICIs) presented as a myocardial infarction and worsened by severe cardiogenic shock.
- The rare occurrence of intraventricular thrombus formation in ICI-related myocarditis complicates diagnosis, particularly when distinguishing it from tumor masses in cancer patients.
- Effective diagnosis requires thorough clinical assessment and advanced imaging techniques, as cardiovascular complications from ICIs, though infrequent, can have high mortality rates.
Article Synopsis
- - The study focused on anti-synthetase syndrome (ASSD), a rare autoimmune disease, aiming to identify clinical and lab features for potential classification criteria.
- - Researchers analyzed data from 948 ASSD patients and 1077 control subjects, finding that certain symptoms like arthritis and specific autoantibodies were more common in ASSD cases.
- - The findings will assist clinicians in diagnosing ASSD and contribute to creating more standardized, data-driven classification criteria for the syndrome.
Case report of an ST-elevation Myocardial Infarction-like presentation of an immune checkpoint (PD-1/PD-L1) inhibitor-associated myocarditis.
Eur Heart J Case Rep
September 2024
Department of Cardiology, General Hospital Sint-Jan, Ruddershove 10, 8000 Bruges, Belgium.
Background: ICI-associated myocarditis is a rare but severe and potentially life-threatening complication that typically manifests shortly after treatment initiation. It may present in many different ways, ranging from fulminant to non-fulminant, even including clinical and electrocardiographic findings mimicking ST-elevation Myocardial Infarction (STEMI).
Case Summary: A 72-year-old woman with a history of non-small cell lung carcinoma presented at the emergency department with symptoms of general asthenia and chest pain, following recent ICI-therapy initiation.
Immune-Related Adverse Events Induced by Immune Checkpoint Inhibitors and CAR-T Cell Therapy: A Comprehensive Imaging-Based Review.
Cancers (Basel)
July 2024
Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland.
Immunotherapy has revolutionized oncology care, improving patient outcomes in several cancers. However, these therapies are also associated with typical immune-related adverse events due to the enhanced inflammatory and immune response. These toxicities can arise at any time during treatment but are more frequent within the first few months.
View Article and Find Full Text PDFDilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes.
Cardiovasc Pathol
September 2024
Division of Medical Genetics, Department of Experimental Medicine, Sapienza University, San Camillo-Forlanini Hospital, Rome, Italy.
Dilated cardiomyopathy (DCM) is defined as left ventricular enlargement accompanied by systolic dysfunction not explained by abnormal loading conditions or coronary heart disease. The DCM clinical spectrum is broad, ranging from subclinical to severe presentation with progression to end stage heart failure. To date, different genetic loci have been found to have moderate/definitive evidence for causality in DCM and pathogenic variants in the TTN gene represent the main genetic determinant.
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