Objective: To examine the effectiveness of posterior tibial nerve stimulation (PTNS) for the treatment of fecal and urinary incontinence in children with malformations of the bowel or neurological pathologies.
Introduction: Treatment of fecal and urinary leaks, in cases of congenital malformations remains a challenge. Recent studies in adults have shown the effectiveness of PTNS.
Method: Eight children: 4 with anorectal malformations, 3 with neurological causes (1 medullary lipoma, 1 Arnold Chiari malformation, 1 sacrococcygeal teratoma) and 1 with Hirschsprung's disease presenting with serious anal incontinence, despite extensive bowel management during at least 2 years, were treated with PTNS. Six children had associated urinary leaks. Jorge-Wexner score for defecation and Schurch score for urine were used before treatment and after the second and sixth months of stimulation.
Results: After six months, five patients had no more fecal leakage, two patients were improved and one did not respond. Five out of the 6 patients with urinary leaks were continent at 6 months.
Conclusion: PTNS is a noninvasive technique and painless modality which seems to be effective for the treatment of fecal and urinary leaks in children even with congenital digestive pathologies or neurological malformations. These results will be confirmed in a prospective study.
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http://dx.doi.org/10.1016/j.jpedsurg.2014.05.033 | DOI Listing |
Theranostics
January 2025
Department of Nephrology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, 100029, China.
The tertiary structure of normal podocytes prevents protein from leaking into the urine. However, observing the complexity of podocytes is challenging because of the scale differences in their three-dimensional structure and the close proximity between neighboring cells in space. In this study, we explored podocyte-secreted angiopoietin-like 4 (ANGPTL4) as a potential morphological marker via super-resolution microscopy (SRM).
View Article and Find Full Text PDFCureus
December 2024
Hospital Medicine, Cleveland Clinic Abu Dhabi, Abu Dhabi, ARE.
Acute kidney injury (AKI) is typically classified as prerenal, renal, or postrenal in etiology, with postrenal often referring to obstructive causes. However, certain uncommon conditions, such as intraperitoneal urinary leaks, may not fit clearly into these categories. In patients with a recent history of pelvic procedure, a complication such as intraperitoneal urinary leak can mimic AKI due to urine reabsorption across the peritoneum.
View Article and Find Full Text PDFTransl Androl Urol
November 2024
Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT, USA.
Background: There is limited data within the urologic literature regarding bowel complications and leak rates following surgery requiring ileocolic anastomoses such as right colon pouch (RCP) and continent cutaneous ileocecocystoplasty (CCIC). We aimed to establish ileocolic anastomotic leak rates in urologic reconstructive surgery and determine bowel-related complications following RCP and CCIC surgeries.
Methods: We reviewed adult patients who underwent RCP or CCIC (2010-2022), investigating patient characteristics, perioperative variables, and outcomes.
Objective: Aim: To improve the treatment results of patients with anastomotic leaks by studying genetic predisposition.
Patients And Methods: Materials and Methods: The object of this prospective study were 17 patients with anastomotic leaks. A group of 80 practically healthy people was tested as control.
Chem Biomed Imaging
November 2024
Department of Systems Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
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