Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.biochem.5b00323 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeted correction of megabase-scale duplication in induced pluripotent stem cells and impacts on gene expression.
PeerJ
January 2025
Genomic Mechanisms of Ontogenesis, Institute of Cytology and Genetics, Novosibirsk, Novosibirsk, Russia.
Copy number variations of the human gene, resulting from megabase-scale microdeletions or microduplications in the 3p26.3 region, are frequently implicated in neurodevelopmental disorders such as intellectual disability and developmental delay. However, duplication of the full-length human gene presents with variable penetrance, resulting in phenotypes that range from neurodevelopmental disorders to no visible pathologies, even within the same family.
View Article and Find Full Text PDFInvestigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis.
Thromb J
January 2025
Department of Vascular Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, China.
Background: Venous thromboembolism (VTE) is a common vascular disease with a significant global burden, influenced by multiple factors, such as genetic, environmental, and immune components. Immune responses and shifts in immune cell profiles are closely linked to the development and progression of VTE, yet current studies are limited by confounding factors and reverse causation. To address these limitations, this study uses Mendelian randomization to explore the causal relationship between immune cell traits and VTE, aiming to provide insights into underlying mechanisms.
View Article and Find Full Text PDFSwin-transformer for weak feature matching.
Sci Rep
January 2025
Department of Computer Science and Technology, Qilu University of Technology, No. 3501 Daxue Road, Jinan, 250300, Shandong, China.
Feature matching in computer vision is crucial but challenging in weakly textured scenes due to the lack of pattern repetition. We introduce the SwinMatcher feature matching method, aimed at addressing the issues of low matching quantity and poor matching precision in weakly textured scenes. Given the inherently significant local characteristics of image features, we employ a local self-attention mechanism to learn from weakly textured areas, maximally preserving the features of weak textures.
View Article and Find Full Text PDFEffects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults.
Sci Rep
January 2025
Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou, Zhejiang Provinces, People's Republic of China.
Middle-aged and older adults with chronic diseases are more likely to encounter sleep difficulty and have a reduced Health-Related Quality of Life (HRQoL), but there is little research on their possible mechanisms. Therefore, the main objective of this study was to explore how sleep difficulty mediates the impact of chronic diseases on the HRQoL of middle-aged and older adults. The survey data were from a cross-sectional study carried out in 2019 in Hangzhou, China.
View Article and Find Full Text PDF[Guiding significance of intra-articular sagittal reduction in the treatment of tibial plateau fractures].
Zhongguo Gu Shang
January 2025
Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China.
Tibial plateau fracture is a fracture involving the proximal articular surface of the tibia, and its injury mechanism is complex, the fracture morphology is different, and it is often accompanied by different degrees of soft tissue injury, which is difficult to diagnose and treat. In recent years, the research hotspot has focused on solving the reduction and fixation of the posterior lateral column of the tibial plateau, because it has been clinically found that the residual sagittal plane after tibial plateau fracture is insufficient reduction or loss of reduction leads to knee joint dysfunction. The posterior inclination angle of the tibial plateau is an important parameter to describe the sagittal alignment of the tibia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!