A diagonal optically active transition in a quantum cascade detector is introduced as optimization parameter to obtain quality factor matching between a photodetector and a cavity. A more diagonal transition yields both higher extraction efficiency and lower noise, while the reduction of the absorption strength is compensated by the resonant cavity. The theoretical limits of such a scheme are obtained, and the impact of losses and cavity processing variations are evaluated. By optimizing the quantum design for a high quality cavity, a specific detectivity of 10(9) Jones can be calculated for λ = 8μm and T = 300K.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1364/OE.23.006283 | DOI Listing |
J Biomol Struct Dyn
December 2024
Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, India.
In the relentless pursuit of unraveling the intricate pathophysiology of Alzheimer's disease (AD), amyloid β (Aβ) proteins emerge as focal points due to their pivotal role in disease progression. The pathological hallmark of AD involves the aberrant aggregation of Aβ peptides into amyloid fibrils, precipitating a cascade of neurodegenerative events culminating in cognitive decline and neuronal loss. This study adopts a computational framework to investigate the potential therapeutic efficacy of novel biosurfactants (BS) in mitigating Aβ fibril formation.
View Article and Find Full Text PDFJ Struct Biol
December 2024
Advanced Research Institute, Institute of Science Tokyo, 1-5-45 Yushima Bunkyo-ku 113-8510, Tokyo, Japan. Electronic address:
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive lysophospholipids derived from cell membranes that activate the endothelial differentiation gene family of G protein-coupled receptors. Activation of these receptors triggers multiple downstream signaling cascades through G proteins such as Gi/o, Gq/11, and G12/13. Therefore, LPA and S1P mediate several physiological processes, including cytoskeletal dynamics, neurite retraction, cell migration, cell proliferation, and intracellular ion fluxes.
View Article and Find Full Text PDFMicrosyst Nanoeng
December 2024
College of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China.
Metasurface with natural static structure limits the development of dynamic metasurface holographic display with rapid response and broadband. Currently, liquid crystal (LC) was integrated onto the metasurface to convert the passive metasuface into an active one. But, majority of LC-assisted active metasurfaces often exhibit trade-offs among degree of freedom (DoF, typically less than 2), information capacity, response speed, and crosstalk.
View Article and Find Full Text PDFPhotoacoustics
February 2025
Dipartimento di Scienze di Base ed Applicate per l'Ingegneria, Sapienza Università di Roma, Rome 00161, Italy.
A compact and robust optical excitation photoacoustic sensor with a self-integrated laser module excitation and an optimized differential resonator was developed to achieve high sensitivity and full linear range detection of carbon dioxide (CO) based on dual modes of wavelength modulated photoacoustic spectroscopy (WMPAS) and resonant frequency tracking (RFT). The integrated laser module equipped with three lasers (a quantum cascade laser (QCL), a distributed feedback laser (DFB) and a He-Ne laser) working in a time-division multiplexing mode was used as an integrated set of spectroscopic sources for detection of the designated concentration levels of CO. With the absorption photoacoustic mode, the WMPAS detection with the QCL and DFB sources was capable of CO detection at concentrations below 20 %, yielding a noise equivalent concentration (NEC) as low as 240 ppt and a normalized noise equivalent absorption coefficient (NNEA) of 4.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Cuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, the non-tumor-specific release of Cu ions can induce cuproptosis and cause irreversible damage to normal tissues. To maximize the therapeutic effects of tumor-specific cuproptosis, this work reports for the first time the regulation of degradation behaviors of Cu-based nanomaterials using graphene quantum dots (GQDs) as a protection layer.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!