Mathematical models are now an important tool for studying cardiac electrophysiology and arrhythmias. Utilizing these models to quantify behavior and make predictions requires solving the models computationally using numerical schemes. We discuss different solution methods and other computational considerations for simulating cardiac action potentials in single cells and multicellular preparations.
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http://dx.doi.org/10.1007/978-1-4939-2572-8_5 | DOI Listing |
JACC Clin Electrophysiol
December 2024
Cardiac Arrhythmia Service, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
JACC Clin Electrophysiol
December 2024
Kansas City Heart Rhythm Institute and Research Foundation, Kansas City, Kansas, USA. Electronic address:
Left atrial appendage occlusion (LAAO) has become an important therapeutic target for stroke prevention in patients with nonvalvular atrial fibrillation. Over the past 2 decades, several advancements in LAAO devices (percutaneous and surgical) have been made for stroke prevention and arrhythmia therapy. However, there are several unanswered questions regarding optimal patient selection, the preferred LAAO approach and device, the management of periprocedural and postprocedural complications, including pericardial effusion, device-related thrombus, and device leaks.
View Article and Find Full Text PDFJACC Clin Electrophysiol
December 2024
St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom; William Harvey Research Institute, Queen Mary University of London, London, United Kingdom. Electronic address:
Background: The sympathetic autonomic nervous system plays a major role in arrhythmia development and maintenance. Historical preclinical studies describe preferential increases in cardiac sympathetic tone upon selective stimulation of the subclavian ansae (SA), a nerve cord encircling the subclavian artery.
Objectives: This study sought to define, for the first time, the functional anatomy and physiology of the SA in humans using a percutaneous approach.
Turk Kardiyol Dern Ars
January 2025
Department of Cardiology, University of Health Sciences, Derince Training and Research Hospital, Kocaeli, Türkiye.
Cardiac implantable electronic device (CIED) implantation is a diagnostic and therapeutic method that is being employed on a growing number of patients globally. These devices require long-term follow-up and monitoring, and after implantation, regular follow-ups are conducted at specific intervals. These follow-ups provide crucial information about both the device and the patient, aiding in diagnosis and guiding treatment.
View Article and Find Full Text PDFJ Clin Med
January 2025
Division of Cardiology, Department of Internal Medicine, Bassett Medical Center, 1 Atwell Rd, Cooperstown, NY 13326, USA.
: Leadless pacemakers offer a safe and effective alternative pacing strategy. However, limited data are available for patients with end stage renal disease (ESRD), a population of significant relevance. Using the Nationwide Readmission Database, we extracted data from all adult patients with ESRD who underwent traditional transvenous or leadless pacemaker implantation between 2016 and 2021.
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