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Exosome-Integrated Hydrogels for Bone Tissue Engineering.
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November 2024
Department of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea.
Article Synopsis
- Exosome-integrated hydrogels are innovative materials in bone tissue engineering that utilize exosomes' biological properties to boost healing.
- These hydrogels provide a controlled way to deliver therapeutic agents directly to injury sites, enhancing tissue regeneration.
- The review discusses how these exosome-hydrogel combinations can improve bone repair mechanisms and outlines challenges like scalability and regulatory issues while highlighting future research directions.
The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations.
Int J Dev Biol
December 2024
Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, China.
The axolotl, a legendary creature with the potential to regenerate complex body parts, is positioned as a powerful model organism due to its extraordinary regenerative capabilities. Axolotl can undergo successful regeneration of multiple structures, providing us with the opportunity to understand the factors that exhibit altered activity between regenerative and non-regenerative animals. This comprehensive review will explore the mysteries of axolotl regeneration, from the initial cellular triggers to the intricate signaling cascades that guide this complex process.
View Article and Find Full Text PDFTargeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies.
CNS Neurosci Ther
December 2024
Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.
Article Synopsis
- Spinal cord injury (SCI) is a major neurological disorder causing serious motor, sensory, and autonomic issues, primarily due to poor axon regeneration and remyelination.
- Recent research highlights new therapeutic strategies that target key molecules and pathways to enhance myelin repair in SCI, using both lab and animal studies.
- The review emphasizes the challenges in applying these findings to clinical settings, focusing on safety and delivery methods, while positing targeted remyelination therapies as a hopeful treatment approach for SCI.
Bioactive Milk-Derived Nutrient MFG-E8 Ameliorates Skeletal Muscle Atrophy Induced by Mitochondria Damage in Aging Rat via Activating MAPK/ERK Signaling Pathway.
J Dairy Sci
December 2024
Dairy Nutrition and Function, Key Laboratory of Sichuan Province, New Hope Dairy Co., Ltd., Chengdu, Sichuan, 610023, China; Chengdu Molecular Power Biotechnology Co., Ltd., Chengdu, Sichuan, 611732; China.
Sarcopenia is an age-related muscle loss, fiber number and decreased regenerative capacity with increased abundance of ROS levels and electron transport chain (ETC) abnormalities. The aim of the study is to investigate the anti-sarcopenia effect of MFG-E8 in alleviating skeletal muscle dysfunction induced by D-gal, reveal the mechanism on promoting myoblast cell proliferation and mediating cell cycle. In vivo experiment showed that MFG-E8 can improve the anti-oxidant status and increase soleus muscle mass (35.
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