AI Article Synopsis
- The paper investigates how the physical and chemical properties of certain drugs affect their absorption through the skin when using nanosuspensions, which are tiny particles of drugs suspended in a liquid.
- Four different drug nanosuspensions were created using a high-pressure homogenization method, and all had the same stabilizer and similar particle sizes.
- Results showed that these nanosuspensions had a significantly higher transdermal absorption rate compared to larger microsuspensions, with key factors like log P and pKa influencing this absorption, particularly for drugs with specific values of these properties.
Article Abstract
The purpose of this paper was to study the influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions. Four drug nanosuspensions were produced by high-pressure homogenization technique, which were the same in stabilizer and similar in particle size. Differential scanning calorimetry and powder X-ray diffraction analysis showed that the crystalline state of the nanocrystals did not change. In vitro permeation study demonstrated that the drug nanosuspensions have a higher rate of permeation that ranged from 1.69- to 3.74-fold compared to drug microsuspensions. Correlation analysis between drug physicochemical properties and Jss revealed that log P and pKa were factors that influenced the in vitro transdermal absorption of hydrophobic drug nanosuspensions, and drugs with a log P value around 3 and a higher pKa value (when pKa < pH+2) would gain higher Jss in this paper.
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| http://dx.doi.org/10.3109/03639045.2015.1031137 | DOI Listing |
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