X-ray fluorescence computed tomography (XFCT) is a stimulated emission tomography modality that maps the three-dimensional (3D) distribution of elements. Generally, XFCT is done by scanning a pencil-beam across the sample. This paper presents a feasibility study of full-field XFCT (FF-XFCT) for 3D elemental imaging. The FF-XFCT consists of a pinhole collimator and X-ray imaging detector with no energy resolution. A prototype imaging system was set up at the Shanghai Synchrotron Radiation Facility (SSRF) for imaging the phantom. The first FF-XFCT experimental results are presented. The cadmium (Cd) and iodine (I) distributions were reconstructed. The results demonstrate FF-XFCT is fit for 3D elemental imaging and the sensitivity of FF-XFCT is higher than a conventional CT system.
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http://dx.doi.org/10.1039/c4an02401j | DOI Listing |
Phys Med Biol
November 2024
Department of Engineering Physics, Tsinghua University, Beijing 100084, People's Republic of China.
High atomic number element nanoparticles have shown potential in tumor diagnosis and therapy. X-ray fluorescence computed tomography (XFCT) technology enables quantitative imaging of high atomic number elements by specifically detecting characteristic x-ray signals. The potential for further biomedical applications of XFCT depends on balancing sensitivity, spatial resolution, and imaging speed in existing XFCT imaging systems.
View Article and Find Full Text PDFPhys Med Biol
February 2023
School of Biomedical Engineering, Air Force Medical University, Xi'an, 710000, People's Republic of China.
X-ray fluorescence computed tomography (XFCT) is a promising noninvasive technique forimaging of high-Z elements (e.g. gadolinium (Gd) or gold (Au)).
View Article and Find Full Text PDFAnalyst
May 2015
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Zhangheng Road 239, 201204 Shanghai, China.
X-ray fluorescence computed tomography (XFCT) is a stimulated emission tomography modality that maps the three-dimensional (3D) distribution of elements. Generally, XFCT is done by scanning a pencil-beam across the sample. This paper presents a feasibility study of full-field XFCT (FF-XFCT) for 3D elemental imaging.
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