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Systemic Innate Immune System Restoration as a Therapeutic Approach for Neurodegenerative Disease: Effects of NP001 on Amyotrophic Lateral Sclerosis (ALS) Progression.
Biomedicines
October 2024
Neuvivo, Inc., Palo Alto, CA 94301, USA.
Background/objective: Amyotrophic lateral sclerosis (ALS) is a diagnosis that incorporates a heterogeneous set of neurodegenerative processes into a single progressive and uniformly fatal disease making the development of a uniformly applicable therapeutic difficult. Recent multinational ALS natural history incidence studies have identified systemic chronic activation of the innate immune system as a major risk factor for developing ALS. Persistent immune activation in patients with ALS leads to loss of muscle and lowering of serum creatinine.
View Article and Find Full Text PDFLong-Term Stability and Efficacy of NCT Solutions.
Int J Mol Sci
August 2024
Physical Sciences Division, University of Washington Bothell, Bothell, WA 98011, USA.
To realize the potential for the use of -chlorotaurine (NCT) in healthcare, a better understanding of the long-term stability of the compound in water is needed. An array of analytical procedures is required that can measure changes in NCT concentration over time and allow for the detection and identification of contaminants and likely degradation end products. We used UV-Vis and NMR spectroscopy, HPLC, and LCMS to establish the stability of NCT in solutions subjected to prolonged ambient and elevated temperatures.
View Article and Find Full Text PDFActivity of -Chlorotaurine against Periodontal Pathogens.
Int J Mol Sci
July 2024
Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, A-6020 Innsbruck, Austria.
Dental plaque bacteria play an important role in the pathogenicity of periodontitis and peri-implantitis. Therefore, antimicrobial agents are one means of treatment. -chlorotaurine (NCT) as an endogenous well-tolerated topical antiseptic could be of advantage for this purpose.
View Article and Find Full Text PDF-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies.
Int J Mol Sci
July 2024
Department of Biochemistry and Medical Chemistry, Dnipro State Medical University, 49044 Dnipro, Ukraine.
-chlorotaurine (NCT) is a broad-spectrum antimicrobial agent with outstanding tolerability, effective for topical and inhalation use. This paper presents the results of studies of single and repeated intravenous infusions of NCT to laboratory animals. The studies were conducted on female Wistar Han rats.
View Article and Find Full Text PDFTolerability of N-chlorotaurine in comparison with routinely used antiseptics: an in vitro study on chondrocytes.
Pharmacol Rep
August 2024
Division of Orthopaedics, Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Background: Currently, povidone-iodine (PVP-I) and hydrogen peroxide (HO) are frequently used antiseptics in joint infections, but the cytotoxic effects of these solutions are already reported. N-chlorotaurine (NCT) shows a broad-spectrum bactericidal activity and is well tolerated in various tissues, but its effect on human chondrocytes is unknown. The purpose of this study was to assess the cytotoxic effect of NCT, PVP-I, and HO on human chondrocytes compared to a control group in an in vitro setting to get first indications if NCT might be a promising antiseptic in the treatment of septic joint infections for the future.
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