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Titanium Dioxide Nanoparticles Negatively Influence Gill Metabolism in .
Metabolites
December 2024
Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China.
Background: In recent years, titanium dioxide (TiO) nanoparticles (NPs) have been widely used in various industries due to their favorable chemical properties, and their contamination of the environment has attracted much attention, especially to aquatic animals.
Methods: Therefore, we assessed the impact of TiO NPs (5 mg/L) on the marine bivalve, pearl oyster (), especially gill metabolism. Pearl oysters were exposed to seawater containing 5 mg/L TiO NPs for 14 days, followed by 7 days of recovery in untreated seawater.
Study on the protective mechanism of Xuemaitong Capsule against acute myocardial ischemia rat based on network pharmacology and metabolomics.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
School of Pharmacy and Key Laboratory of Basic Pharmacology Ministry Education and Joint International Research Laboratory of Ethnomedicine Ministry of Education, Zunyi Medical University, Zunyi 563000, China. Electronic address:
Background: Xuemaitong Capsule (XMT) is a widely recognized traditional Miao medicine extensively utilized in Chinese clinical settings. Previous studies have demonstrated XMT protective effects against acute myocardial ischemia (AMI). However, the mechanism by which XMT provides protection to AMI rats is yet to be fully understood.
View Article and Find Full Text PDFCsLCD and CsDCD are involved in nitric oxide-enhanced salt tolerance in cucumber seedlings.
Physiol Plant
November 2024
College of Horticulture, Gansu Agricultural University, Lanzhou, China.
Nitric oxide (NO) and hydrogen sulphide (HS) play important roles in plant growth, development and environmental adaptation. Currently, there is few information on the mechanism by which HS may be involved in NO-induced salt tolerance. In this study, cucumber was used to investigate the role of NO and HS and their relationship under salt stress.
View Article and Find Full Text PDFThe involvement of nicotinate and nicotinamide metabolism pathway in attenuating benzene-induced mouse hematotoxicity.
Ecotoxicol Environ Saf
December 2024
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Benzene exposure has been linked to various adverse health effects. However, the effective strategy for prevention or treatment of benzene-induced hematotoxicity remains unsolved. We previously administrated hepatocyte-specific deletion of Ppp2r1a gene (encoding PP2A Aα subunit) mice with benzene via inhalation for 28 days, and found homozygote (HO) mice exhibited alleviative hematotoxicity compared with wild type (WT) mice.
View Article and Find Full Text PDFUnraveling the liver metabolomic profile of ADB-BUTINACA-induced hepatotoxicity.
Ecotoxicol Environ Saf
December 2024
National Narcotics Laboratory Zhejiang Regional Center, Hangzhou 310053, China. Electronic address:
ADB-BUTINACA, as a new psychoactive substance, can induce physical and psychological dependence. However, the systemic biological impact of ADB-BUTINACA on hepatic metabolomics remains uncertain. The metabolic spectrum in rat livers following exposure to three varying doses of ADB-BUTINACA (0.
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