AI Article Synopsis
- Researchers used clearing methods to make mouse brains transparent, enabling high-resolution 3D imaging of neural networks.
- They analyzed white matter in BTBR mice, confirming absence of the corpus callosum and finding an unusual commissure near the third ventricle.
- The study utilized diffusion tensor imaging (DTI) and two-photon imaging to reveal details about the structure of white matter and the arrangement of fibers in the brain.
Article Abstract
Clearing methods that render the brain optically transparent allow high-resolution three-dimensional (3D) imaging of neural networks. We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identified an abnormal commissure close to the third ventricle. DTI and cleared-brain two-photon imaging revealed that these commissural fibers constituted a frontal clustering of the ventral hippocampal commissure and provided a detailed assessment of white matter structure in mice.
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| http://dx.doi.org/10.2463/mrms.2014-0142 | DOI Listing |
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