Previous studies had shown that CXC chemokine ligand-12 (CXCL12) plays a significant role in animal models of ischemic stroke, but its role in human stroke is unclear. The aim of this study was to test the relationship between elevated serum circulating CXCL12 levels and the 1-year stroke recurrence in Chinese patients with acute ischemic stroke (AIS). All consecutive patients with first-ever acute ischemic stroke from January 2011 to September 2013 were recruited to participate in the study. Serum levels of CXCL12 and National Institute of Health Stroke Scale (NIHSS) were measured at the time of admission. Logistic regression analysis was used to evaluate the stroke recurrence according to serum CXCL12 levels. Receiver operating characteristic (ROC) curve was used to evaluate the accuracy of serum CXCL12 in predicting stroke recurrence. Clinical follow-up was performed at 1 year. In our study, 248 patients finished the 1-year follow-up. At 1-year follow-up, 31 patients had a recurrence ischemic stroke. The median CXCL12 levels were significantly higher in those who sustained a recurrence ischemic stroke compared with those who did not [24.2 ng/mL (IQR 15.4-33.7) vs 6.5 ng/mL (IQR 3.4-10.2); Z = 8.258, P < 0.0001]. In multivariate analysis, there was an increased risk of stroke recurrence associated with serum CXCL12 levels ≥12.15 ng/mL (OR 9.122, 95 % CI 6.103-15.104) after adjusting for above possible confounders. The time to recurrence stroke distribution between patients with baseline CXCL12 levels ≥12.15 ng/mL and those with baseline CXCL12 levels <12.15 ng/mL were significantly different (P < 0.0001, log-rank test). Elevated circulating CXCL12 levels at admission are strongly associated with the future recurrence of ischemic stroke in Chinese patients with AIS. Further studies are warranted to confirm this association and define the role for CXCL12 as a novel predictor biomarker for stroke recurrence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12035-015-9151-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Left-sided appendicitis revealing situs inversus: diagnostic challenges and emergency surgical management strategies - a case report.
J Surg Case Rep
March 2025
Department of Visceral Surgery and Digestive Oncology A, Mohammed VI University Hospital, BP 4806 Oujda Universite, 60049 Oujda, Morocco.
Situs inversus is a rare congenital anomaly that results in the transposition of the abdominal organs, leading to atypical clinical presentations, such as left-sided appendicitis. Acute appendicitis is the most common cause of right iliac fossa pain; however, its occurrence on the left side is exceedingly rare and often leads to diagnostic delays, which may result in serious complications such as peritonitis if not promptly addressed. Imaging modalities, particularly computed tomography (CT), play a critical role in the anatomical and pathological diagnosis, thereby guiding appropriate surgical management.
View Article and Find Full Text PDFIntermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate.
Life Metab
April 2025
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, 180 Fenglin Road, Shanghai 200032, China.
Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alternating periods of eating and fasting, has shown cardiovascular benefits, but its effect on platelet activation is unclear.
View Article and Find Full Text PDFGenetic Overlap Between Obstructive Sleep Apnea and Ischemic Stroke: A Large-Scale Genome-Wide Cross-Trait Analysis.
Nat Sci Sleep
March 2025
Department of Rehabilitation Medicine and National Clinical Research Base of Traditional Chinese Medicine, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, 350004, People's Republic of China.
Background: To further understand the complex relationship between Obstructive Sleep Apnea (OSA) and ischemic stroke, this study explores the role of genetic factors in the comorbidity of these two conditions.
Methods: Based on large-scale available Genome-Wide Association Studies (GWAS) for OSA and ischemic stroke, we conducted a multi-level cross-trait analysis. First, we utilized Linkage Disequilibrium Score Regression (LDSC) to analyze the genetic correlation between the two diseases.
Clarity Amidst the Smoke: Moyamoya Disease, a Diagnosis Not to Be Missed.
Cureus
February 2025
Internal Medicine, Farwaniya Hospital, Kuwait City, KWT.
Moyamoya disease (MMD) is a rare, progressive cerebrovascular disorder characterized by the bilateral stenosis of the internal carotid artery (ICA) and its proximal vessels, leading to the formation of compensatory smoke-like collateral vessels. This report describes the case of a 33-year-old Philippine woman who presented with acute right-sided hemiparesis and had a history of recurrent transient ischemic attacks (TIAs) with similar symptoms. Neuroimaging revealed intracranial hemorrhage and characteristic bilateral occlusion of the internal carotid artery (ICA), middle cerebral artery (MCA), and anterior cerebral artery (ACA) with collateral vessel formation, indicative of moyamoya disease.
View Article and Find Full Text PDFEffects of intermittent theta burst stimulation on upper limb motor recovery in early stroke patients: an fNIRS study.
Front Neurol
February 2025
Department of Rehabilitation Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Objective: To explore the recovery of upper limb motor function and the changes in cortical functional connectivity in patients with early subcortical small infarcts accompanied by severe upper limb motor dysfunction (PESSUM) after intermittent theta burst stimulation (iTBS) via functional near-infrared spectroscopy (fNIRS) and to explore the related mechanisms.
Methods: We enrolled 56 subcortical ischemic stroke patients with FMA-UE ≤28 and randomly assigned them to receive either genuine (TG, = 29) or sham (CG, = 23) iTBS plus standard rehabilitation over 8 days. fNIRS was used to monitor cerebral HbO, HbD, and HbT concentrations, and RSFC changes were analyzed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!