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Exposure to Environmental Toxins & Autoimmune Conditions.
Integr Med (Encinitas)
March 2024
Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, MA, USA; Department of Preventive Medicine, Loma Linda University School of Medicine, USA.
The incidence of autoimmunity is growing rapidly worldwide. Many epidemiological studies have found environmental factors, such as toxic chemicals, to be a key factor in this rapid progression. Many mechanisms that can cause immune dysregulation and autoimmune reactivity from toxic chemical exposure to subsets of individuals with genetic susceptibility in immune regulatory genes have been identified.
View Article and Find Full Text PDFThe Relationships between Intestinal Permeability and Target Antibodies for a Spectrum of Autoimmune Diseases.
Int J Mol Sci
November 2023
Independent Researcher, Puerto Vallarta 48300, Jalisco, Mexico.
The worldwide prevalence of autoimmune diseases that have limited treatment options and preventive strategies is rapidly rising. There is growing evidence that the microbiota and the integrity of the intestinal barrier play a role in autoimmune diseases. The potential to evaluate intestinal barrier integrity for susceptible individuals and to determine whether restoring intestinal junction integrity impacts autoimmune diseases is an important area of research that requires further attention.
View Article and Find Full Text PDFFunctional Medicine Approaches to Neurodegeneration.
Phys Med Rehabil Clin N Am
August 2022
Department of Neurology, Harvard Medical School, Boston, MA 02155, USA; Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02155, USA; Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA. Electronic address:
Neurodegenerative diseases impact more than 6 million Americans, and current predictions estimate the rates of neurodegenerative diseases will double in the next 30 years. These diseases are progressive with increasing loss of brain function throughout their course. Overtime, those suffering from neurodegenerative diseases will lose their ability to work and function efficiently in society.
View Article and Find Full Text PDFExposure to Environmental Toxins and Autoimmune Conditions.
Integr Med (Encinitas)
April 2021
is affiliated with Harvard Medical School; the Department of Neurology, Massachusetts General Hospital; and the Department of Preventive Medicine, Loma Linda University School of Medicine.
The incidence of autoimmunity is growing rapidly worldwide. Many epidemiological studies have found environmental factors, such as toxic chemicals (persistent organic pollutants, toxic metals, solvents, endocrine disruptors), to be a key factor in this rapid progression. Numerous mechanisms have been identified that can cause immune dysregulation and autoimmune reactivity from toxic chemical exposure to subsets of individuals who have genetic susceptibility in immune regulatory genes.
View Article and Find Full Text PDFReaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases.
Front Immunol
February 2021
Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA, United States.
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more.
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