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The introduction of faricimab, a drug targeting both vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2, has enabled the implementation of the highly effective dual inhibition strategy in real clinical practice for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME), both previously treated with intravitreal injections and newly diagnosed. This article presents a series of 11 clinical cases involving patients with nAMD and DME who received loading doses of faricimab and continued ophthalmological observation. Among them, three patients with nAMD and two with DME were treatment-naïve, while the others were switched from alternative therapies to faricimab.
View Article and Find Full Text PDFEndogenetic Carbon Dot Strategy within Melamine-Formaldehyde Microspheres for Multifunctional Hybrid Fluorescence/Room-Temperature Phosphorescence Applications in Dry States and Aqueous Environments.
ACS Appl Mater Interfaces
December 2024
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
Developing hybrid fluorescence (FL)/room-temperature phosphorescent (RTP) materials in dry-state, aqueous, and organic solvents holds paramount importance in broadening their applications. However, it is extremely challenging due to dissolved oxygen and solvent-assisted relaxation causing RTP quenching in an aqueous environment and great dependence on SiO-based materials. Herein, an efficient endogenetic carbon dot (CD) strategy within melamine-formaldehyde (MF) microspheres to activate RTP of CDs has been proposed through the pyrolysis of isophthalic acid (IPA) molecules and branched-chain intra-microspheres.
View Article and Find Full Text PDFInvestigation of Transient Temperature Rising of Light-Harvesting Complex II by Nonradiative Heat Dissipation at the Protein Level.
J Phys Chem Lett
December 2024
Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.
Light-harvesting complex II (LHCII), the most abundant membrane protein in photosystem II, plays dual roles, i.e., efficient light harvesting and energy transfer to the reaction center under low light conditions and dissipating excess energy as heat to prevent photodamage under high irradiation conditions.
View Article and Find Full Text PDFElectronically Controlled Dual-Wavelength Switchable SRS Fiber Amplifier in the NIR-II Region for Multispectral Photoacoustic Microscopy.
Laser Photon Rev
October 2024
Harvard Medical School, Boston, MA 02114, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Cardiology, Erasmus Medical Center, Rotterdam GD3015, The Netherlands; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Photoacoustic microscopy (PAM) is a high-resolution and non-invasive imaging modality that provides optical absorption contrast. By employing dual- or multiple-wavelength excitation, PAM extends its capabilities to offer valuable spectroscopic information. To achieve efficient multispectral PAM imaging, an essential requirement is a light source characterized by a high repetition rate and switching rate, a ≈microjoule pulse energy, and a ≈nanosecond pulse duration.
View Article and Find Full Text PDFPancreatic Safety of Tirzepatide and Its Effects on Islet Cell Function: A Systematic Review and Meta-Analysis.
Obes Sci Pract
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Background: Endogenous glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) regulate islet cell function. GLP-1 receptor agonists (GLP-1RAs) have been associated with an elevated risk of acute pancreatitis. Data on the pancreatic safety of tirzepatide (a dual GLP-1 and GIP agonist) and its effects on islet cell function in randomized controlled trials (RCTs) are scarce.
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