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Safety and effectiveness of dual therapy for Helicobacter pylori infection and the effect on the glycated hemoglobin level in type 2 diabetes.
Sci Rep
January 2025
Department of Gastroenterology, Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, 68 Gehu Middle Road, Wujing District, Changzhou, 213000, Jiangsu, China.
Patients with diabetes have a high risk of failure of H. pylori eradication therapy. The present study aims to evaluate the efficacy and safety of vonoprazan-amoxicillin (VA) dual therapy for the treatment of H.
View Article and Find Full Text PDFReal-world evidence on the efficacy and safety of vonoprazan-amoxicillin dual therapy for treatment in elderly patients.
World J Gastroenterol
January 2025
Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.
Background: A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of (). While substantial research supports the efficacy and safety of vonoprazan and amoxicillin (VA) dual therapy in the general population, there is still a lack of studies specifically focusing on its safety in elderly patients.
Aim: To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for in elderly patients.
Efficacy of carbonyl cyanide-3-chlorophenylhydrazone in combination with antibiotics against .
Microbiol Spectr
December 2024
National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Institute, Capital Medical University, Beijing, China.
Given the intrinsic resistance of to a wide range of conventional antibiotics, it is urgent to explore new therapeutic approaches to manage this infection effectively. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), a proton pump inhibitor, has shown good bacteriostatic activity against . This study aimed to determine its synergistic antimicrobial effects when combined with commonly used antibiotics.
View Article and Find Full Text PDFAsia-Pacific Survey on the Management of Helicobacter pylori Infection.
J Gastroenterol Hepatol
December 2024
Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Background And Aim: Gastric cancer (GC)-related incidence and mortality rates remain high owing to Helicobacter pylori infection in Asia, and the importance of primary and secondary prevention of GC has been well recognized. We aimed to investigate the extent of overall agreement among clinicians in the Asia-Pacific region regarding the management of H. pylori infection.
View Article and Find Full Text PDFCurcumin reverses high-level tigecycline resistance mediated by different mechanisms in Gram-negative bacteria.
Phytomedicine
December 2024
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan Province, PR China; Henan Province Key Laboratory of Animal Food Pathogens SurveillancePR China. Electronic address:
Background: Tigecycline is one of the few effective treatments for multidrug-resistant bacteria. However, the recent emergence and spread of high-level tigecycline resistance in Enterobacteriaceae have significantly limited its clinical use. To combat this challenge, combining antibiotics with adjuvants has emerged as a promising strategy.
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