The state-of-the-art review of literature on existing views on the association of periodontal diseases with somatic therapeutic pathology (part 1 of the review) and comorbid conditions (part 2 of the review) is submitted. The conclusion about need of carrying out the further multicenter researches which purpose is development of new integrated indicators, in a complex and comprehensively characterizing not only the periodontal status, but also set of available somatic therapeutic pathology, especially at patients of advanced and senile age is drawn.

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