Background: This study investigated whether a personalized life story book and rummage box enhanced well-being and led to changes in behaviour for people with Down syndrome (DS) who have dementia.
Materials And Methods: A randomized single case series design was used with five participants who had DS and a diagnosis of dementia. Participants were invited to take part in three conditions at random (i) life story book, (ii) rummage box and (iii) no-intervention condition.
Results: The two reminiscence conditions were significantly associated with enhanced well-being as compared to the no-intervention condition. However, for one participant, the life story book was associated with significantly higher well-being, while for another participant, the rummage box was associated with significantly higher well-being, suggesting some participants may prefer one method over another.
Conclusions: Personalized life story books and rummage boxes are associated with higher levels of well-being for people with DS and dementia.
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http://dx.doi.org/10.1111/jar.12151 | DOI Listing |
Alzheimers Dement
December 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Background: Factors contributing to cognitive decline in adults include vascular risk factors (hypertension, hyperlipidemia, diabetes), lower education, age, Apolipoprotein E4(ApoE4) and cerebral hypoperfusion. The interplay between aging and vascular processes disrupts cerebral hemodynamics, heightening the risk of cognitive impairment and neurological disorders. Similarly, ApoE4 gene increases the risk of vascular-related cognitive impairment and small vessel disease.
View Article and Find Full Text PDFJ Med Biogr
January 2025
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA.
Marcello Malpighi, renowned as the founder of microscopic anatomy, faced many challenges throughout his life. Among these was his frail health, which deteriorated in his early 40s when he developed kidney stones. He struggled with arthritic pain and heart palpitations, which, along with his renal condition, gradually became worse as he got older.
View Article and Find Full Text PDFPLOS Digit Health
December 2024
Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
Objectives: Evaluating craniofacial phenotype-genotype correlations prenatally is increasingly important; however, it is subjective and challenging with 3D ultrasound. We developed an automated label propagation pipeline using 3D motion- corrected, slice-to-volume reconstructed (SVR) fetal MRI for craniofacial measurements.
Methods: A literature review and expert consensus identified 31 craniofacial biometrics for fetal MRI.
Issues Ment Health Nurs
January 2025
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Friendships are vital for the well-being of young adults, yet their social network is often reduced during episodes of life-disruptive mental distress, such as psychosis. Despite this, our study shows that young adults do either maintain or build friendships during such periods and that these relationships are crucial for recovery in youth. As research on the role of friendships in the recovery journey of this group is limited, this study explores the significance of friendships for young adults engaged in early psychosis interventions to generate insights that can inform mental health recovery practices.
View Article and Find Full Text PDFInt J Environ Res Public Health
November 2024
Department of Architecture, University of Cambridge, Cambridge CB2 1PX, UK.
Background: In response to the rising mental health concerns and cognitive decline associated with the human brain's neurogenesis, which continues until the tenth decade of life but declines with age and is suppressed by poor environments, this pilot study investigates how physical environments may influence public health proxy measures of neurogenesis in humans. This pilot study focuses on the residential environment where people spend most of their time and age in place, exploring the dependency of depression, anxiety, and cognitive impairment variations on spatial and lifestyle variables.
Methods: A total of 142 healthy adults in England completed a survey consisting of PHQ-8, GAD-7, and CFI questionnaires and other questions developed to capture the variance in spatial and lifestyle factors such as time spent at home, house type layout complexity, spaciousness, physical activity, routine and spatial novelty, and perceived loneliness.
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