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MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease. | LitMetric

MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease.

Parkinsonism Relat Disord

Department of Neurology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Neural & Behavioral Sciences, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA.

Published: June 2015

AI Article Synopsis

Article Abstract

Introduction: The motor symptoms and signs of early-onset idiopathic Parkinson's disease (PD) in Hoehn and Yahr (H&Y) stage-1 are generally unilateral. We hypothesized that there would be detectable differences in the quantitative MRI parameters in these PD patients between the hemispheres contralateral to the clinically symptomatic and non-symptomatic body side.

Methods: We tested this hypothesis by comparing transverse relaxation rates and diffusion tensor imaging (DTI) parameters in the substantia nigra and putamen between the two hemispheres contralateral to the symptomatic and non-symptomatic side in H&Y stage-1 PD patients who had onset of symptoms between ages of 40-59 years.

Results: There were quantifiable hemispheric asymmetries in transverse relaxation rates in the substantia nigra, as well as fractional anisotropy and mean diffusivity in the putamen in early PD, which correlated with the unilaterality of motor symptoms as evaluated using the motor portion of the Unified Parkinson's Disease Rating Scale.

Conclusion: Transverse relaxation mapping and DTI demonstrated significant differences between the symptomatic and non-symptomatic hemispheres at the early stage of early-onset PD. These findings support the hypothesis of asymmetric neurodegeneration in the bilateral nigrostriatal pathways in the early stage of the disease.

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Source
http://dx.doi.org/10.1016/j.parkreldis.2015.03.012DOI Listing

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