DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme.

Chem Commun (Camb)

Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.

Published: April 2015

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Article Abstract

We show that nucleotides which are modified with a G-quadruplex-derived DNAzyme are substrates for DNA polymerases. Based on this finding we developed a naked-eye detection system that allows the detection of single nucleotide variations in DNA.

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Source
http://dx.doi.org/10.1039/c5cc01387aDOI Listing

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