AI Article Synopsis
- - The prefrontal cortex is crucial for cognitive functions and is linked to schizophrenia symptoms, showing that dysfunction in this area relates closely to the disorder.
- - Patients with schizophrenia often experience not just typical symptoms but also cognitive disorders, leading to the development of a monkey model to study these cognitive symptoms.
- - Treatment with phencyclidine helps replicate these symptoms, but atypical antipsychotics like clozapine can improve cognitive impairments associated with schizophrenia.
Article Abstract
The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyl-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral impairment might be a specific indicator of schizophrenia-related cognitive impairment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563701 | PMC |
| http://dx.doi.org/10.1007/s12264-014-1506-4 | DOI Listing |
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