AI Article Synopsis
- Adding MRI to annual mammography for women with a family history or BRCA mutations leads to earlier detection of breast cancer, showing benefits like smaller tumor sizes and less aggressive treatment required.
- In a study comparing MRI-screened patients (from MRISC) to matched controls, those who had MRI were linked to a lower rate of metastasis and better metastasis-free survival (MFS).
- Overall, while annual MRI screening significantly enhanced MFS, overall survival differences were less clear, suggesting continued research is needed for long-term benefits.
Article Abstract
Adding MRI to annual mammography screening improves early breast cancer detection in women with familial risk or BRCA1/2 mutation, but breast cancer specific metastasis free survival (MFS) remains unknown. We compared MFS of patients from the largest prospective MRI Screening Study (MRISC) with 1:1 matched controls. Controls, unscreened if<50 years, and screened with biennial mammography if ≥50 years, were matched on risk category (BRCA1, BRCA2, familial risk), year and age of diagnosis. Of 2,308 MRISC participants, breast cancer was detected in 93 (97 breast cancers), who received MRI <2 years before breast cancer diagnosis; 33 BRCA1 mutation carriers, 18 BRCA2 mutation carriers, and 42 with familial risk. MRISC patients had smaller (87% vs. 52%
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http://dx.doi.org/10.1002/ijc.29534 DOI Listing Publication Analysis
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