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Use of recombinant factor VII for tooth extractions in a patient with severe congenital factor VII deficiency: a case report. | LitMetric

AI Article Synopsis

  • Patients with factor VII deficiency face a higher risk of excessive bleeding during and after surgeries, as highlighted by a case of a woman needing a tooth extraction.
  • The patient, who had a severe form of this deficiency, successfully underwent the procedure with careful preoperative planning, including specialized treatments like factor VII infusion.
  • Effective perioperative care is crucial, and since bleeding risk doesn't always align with the severity of the deficiency, consulting a hematologist is essential for optimal management.

Article Abstract

Background And Overview: Patients with factor VII deficiency have an increased risk of prolonged perioperative hemorrhage. In this article, the authors present a case of severe factor VII deficiency in a patient who required tooth extraction.

Case Description: A 44-year-old woman with severe congenital factor VII deficiency sought care for a symptomatic, carious, and nonrestorable maxillary right second molar that required extraction. The authors obtained hematologic consultation, and the patient underwent the extraction under general anesthesia in the inpatient setting. Perioperative management included performing relevant laboratory studies, preoperative recombinant factor VII infusion, and postoperative intravenous aminocaproic acid administration. No hemorrhagic complications occurred throughout the perioperative course.

Conclusions And Practical Implications: The degree of factor VII deficiency correlates poorly with bleeding risk. Perioperative management is variable, requiring preoperative consultation with a hematologist.

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Source
http://dx.doi.org/10.1016/j.adaj.2014.12.022DOI Listing

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