AI Article Synopsis
- Large local reactions (LLRs) are late-phase allergic responses to stings that can cause significant discomfort but have a low chance of leading to anaphylaxis (less than 5%).
- Consulting an allergist can help patients evaluate risks, determine appropriate treatments for future stings, and decide on testing or venom immunotherapy (VIT).
- VIT may be recommended for individuals with frequent, unavoidable sting exposure to effectively reduce the severity of LLRs, while the need for an epinephrine injector depends on exposure frequency, access to medical care, and overall quality of life.
Article Abstract
Large local reactions (LLRs) are IgE-mediated late-phase inflammatory reactions that can cause great morbidity but are associated with a relatively low risk of future anaphylaxis. Patients with LLR may benefit from consultation with an allergist to help clarify the relative risk, to plan the best treatment for future stings, and to determine whether or not to pursue testing or venom immunotherapy (VIT). The chance of anaphylaxis to future stings is <5%, so VIT is not generally recommended to people who have had LLR. Whether to prescribe an epinephrine injector is often determined by the frequency of exposure, the proximity to medical care, and the impact on quality of life. For people who have unavoidable exposure and need treatment almost every year for LLR, VIT can be recommended with confidence that it will significantly and safely reduce the severity of LLR to stings.
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| http://dx.doi.org/10.1016/j.jaip.2015.01.020 | DOI Listing |
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