Adv Protein Chem Struct Biol
CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine (CSIC-University of Seville-UPO), Seville, Spain; Department of Medical Biochemistry, Molecular Biology and Immunology, The University of Seville Medical School, Seville, Spain. Electronic address:
Published: July 2016
Neuropeptides are potentially valuable tools for clinical applications as they offer many distinct advantages over other bioactive molecules like proteins and monoclonal antibodies due to their reduced side effects and simple chemical modifications. Despite such advantages, the difficulty with neuropeptides often relies on their poor metabolic stability and reduced biological activity intervals. Among the neuropeptides, VIP has been identified as a potentially bioactive agent for inflammatory, neurodegenerative, and cancer-related diseases. However, the effective translation of preclinical studies related to VIP to clinical realities faces several major challenges, most of which are commonplace for other neuropeptides. Here, we present recent studies aimed at developing nanostructured organic and inorganic systems either for the appropriate delivery of VIP or for VIP targeting. These technologies stand as an alternative starting point for chemical manipulations of the neuropeptides in order to improve potency, selectivity, or pharmacokinetic parameters.
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http://dx.doi.org/10.1016/bs.apcsb.2014.11.006 | DOI Listing |
BMC Med Educ
January 2025
First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, China.
Background: With the continuous development of educational methods, desktop virtual reality technology has gradually attracted widespread attention. Although current research has shown that this technology can promote learning among nursing students, the mechanism and intrinsic factors are not yet clear. This study aims to explore the mechanisms and factors of the application of desktop virtual reality technology in nursing students' education and discuss the possible outcomes.
View Article and Find Full Text PDFSci Bull (Beijing)
January 2025
State Key Laboratory of Ore Deposit Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China.
It is widely accepted that moderately to highly oxidized magmas are needed to form porphyry copper deposits (PCDs). However, only a few studies have attempted to investigate the effects of variable magmatic fO values on the formation of PCDs. Based on previously published studies, the magma oxygen fugacity of giant PCDs is mainly concentrated between ΔFMQ -0.
View Article and Find Full Text PDFEnviron Res
January 2025
Environment and Climate Change Canada, Ecotoxicology and Wildlife Health Division, National Wildlife Research Centre, Carleton University, Ottawa, ON, K1A 0H3, Canada. Electronic address:
Metabolomics measures low molecular weight endogenous metabolites and changes linked to contaminant exposure in biota. Few studies have explored the relationship between metabolomics and contaminants in Arctic wildlife. We analyzed 239 endogenous metabolites and ∼150 persistent organic pollutants (POPs), including total mercury (THg), in the liver of polar bears and their ringed seal prey harvested from low Canadian Arctic (western Hudson Bay; WHB) and high Arctic (HA) locations during 2015-2016.
View Article and Find Full Text PDFJ Clin Densitom
December 2024
Department of Trauma and Orthopedics at the People's Hospital of Hezhou, Guangxi Zhuang Autonomous Region, China. Electronic address:
Objective: This study aims to systematically assess the therapeutic effects of Traditional Chinese Medicine (TCM) kidney-tonifying methods on osteoporosis in HR+ breast cancer patients after endocrine therapy, and to explore their clinical application value.
Methods: This systematic review and meta-analysis adhered to the PRISMA guidelines and aimed to evaluate the impact of TCM kidney-tonifying methods on osteoporosis in HR+ breast cancer patients after endocrine therapy. Literature searches were conducted through October 2024 in databases including CBM, CNKI, Wanfang Data, PubMed, Web of Science, Cochrane Central, VIP, and renowned TCM databases such as TCM Online.
Poult Sci
January 2025
Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu 611130, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, PR China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education, PR China. Electronic address:
Escherichia coli (E. coli) is a significant pathogen responsible for intestinal infections and foodborne diseases. The rise of antibiotic resistance poses a significant challenge to global public health.
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