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Ferric carboxymaltose with or without phosphate substitution in iron deficiency or iron deficiency anemia before elective surgery - The DeFICIT trial.
J Clin Anesth
December 2024
Institute of Anesthesiology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Background: Iron deficiency anemia in the perioperative setting is treated predominantly with intravenous iron formulation, of which ferric carboxymaltose may induce hypophosphatemia by modulating fibroblast growth factor 23.
Methods: In this single-center, prospective, randomized, double-blind trial, we consented 92 adult patients scheduled for elective major abdominal or thoracic surgery. These patients either had isolated iron deficiency (plasma ferritin <100 ng/mL or transferrin saturation < 20 %) or iron deficiency anemia (hemoglobin (Hb) 100-130 g/L with plasma ferritin <100 ng/mL or transferrin saturation < 20 %).
Increased ambient temperature and hyponatraemia presentations: A ten-year retrospective study at an Australian hospital.
J Clin Endocrinol Metab
November 2024
Department of Endocrinology, Austin Health, Heidelberg, Australia.
Objectives: To determine the relationship between ambient air temperature and the incidence of hyponatraemia in a heat-prone region.
Design And Setting: We conducted a retrospective study that correlated serum sodium concentrations documented at The Austin Hospital in Melbourne over ten years from January 2014 to December 2023, with publicly available temperature data from the Australian Bureau of Meteorology.
Main Outcome Measures: Serum sodium concentrations and incidence of hyponatraemia admissions when correlated to temperature, and following heatwave events, defined as temperature above 30°C over five consecutive days.
Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.
JAMA Cardiol
November 2024
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Article Synopsis
- Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, improved outcomes for heart failure patients in the FINEARTS-HF trial but led to elevated serum potassium levels.
- The study aimed to analyze the frequency of abnormal serum potassium levels (<3.5 mmol/L and >5.5 mmol/L) and the impact of finerenone treatment compared to placebo on patient outcomes.
- Results showed that participants taking finerenone experienced significantly higher potassium levels over time, with increased risk of levels >5.5 mmol/L and reduced risk of levels <3.5 mmol/L, indicating a notable effect of the drug on potassium regulation.
Impella malrotation affects left ventricle unloading in cardiogenic shock patients.
ESC Heart Fail
October 2024
Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Article Synopsis
- The study focused on the effects of Impella malrotation on patients in cardiogenic shock, identifying the malrotation in 36% of cases.
- Findings indicated that those with malrotation experienced significantly worse pulmonary pressures, higher right atrial pressure, and elevated serum lactate levels compared to those without malrotation.
- The conclusions suggest that Impella malrotation leads to suboptimal left ventricular unloading and aggravated pulmonary and right ventricular conditions, though major adverse outcomes did not significantly differ.
Elevated serum cholesterol levels during pregnancy as predictors for postpartum hypercholesterolemia: A prospective cohort study.
Int J Gynaecol Obstet
September 2024
Department of Nutrition and Food Hygiene, School of Public Health, Capital Medical University, Beijing, China.
Objective: To identify the associations between gestational cholesterol levels and the risk of postpartum hypercholesterolemia, and to establish trimester-specific reference values.
Methods: Serum lipids at gestational weeks 6-8, 16, 24, and 36, and 42 days postpartum were derived from 905 pregnant women of a prospective cohort. The major outcome was postpartum hypercholesterolemia.
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