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Biokinetic aspects for biocatalytic remediation of xenobiotics polluted seawater.
J Appl Microbiol
August 2020
Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt.
Aims: This research was conducted to investigate the biocatalytic remediation of xenobiotics polluted seawater using two biocatalysts; whole bacterial cells of facultative aerobic halotolerant Corynebacterium variabilis Sh42 and its extracted crude enzymes.
Methods And Results: One-Factor-at-A-Time technique and statistical analysis were applied to study the effect of initial substrate concentrations, pH, temperature, and initial biocatalyst concentrations on the batch biocatalytic degradation of three xenobiotic pollutants (2-hydroxybiphenyl (2-HBP), catechol and benzoic acid) in artificial seawater (salinity 3·1%). HPLC and gas-chromatography mass spectroscopy analyses were utilized to illustrate the quantitative removal of the studied aromatic xenobiotic pollutants and their catabolic pathway.
Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism.
Biochim Biophys Acta Mol Basis Dis
September 2018
Department of Experimental Medical Science, Lund University, S-221 84 Lund, Sweden. Electronic address:
Prolonged hyperglycemia in poorly controlled diabetes leads to an increase in reactive glucose metabolites that covalently modify proteins by non-enzymatic glycation reactions. Apolipoprotein A-I (apoA-I) of high-density lipoprotein (HDL) is one of the proteins that becomes glycated in hyperglycemia. The impact of glycation on apoA-I protein structure and function in lipid and glucose metabolism were investigated.
View Article and Find Full Text PDFAlcohol Metabolic Inefficiency: Structural Characterization of Polymorphism-Induced ALDH2 Dysfunctionality and Allosteric Site Identification for Design of Potential Wildtype Reactivators.
Protein J
June 2018
Molecular Biocomputation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
Liver mitochondrial aldehyde dehydrogenase 2 (ALDH2) enzyme is responsible for the rapid conversion of acetaldehyde to acetic acid. ALDH2 (E487K) polymorphism results in an inactive allele (ALDH2*2) which cause dysfunctional acetaldehyde metabolism. The 3D structure of an enzyme is crucial to its functionality and a disruption in its structural integrity could result in its metabolic inefficiency and dysfunctionality.
View Article and Find Full Text PDFUnraveling the Nature of Active Sites in Ethanol Electro-oxidation by Site-Specific Marking of a Pt Catalyst with Isotope-Labeled CO.
J Phys Chem Lett
March 2018
Instituto de Electroquímica , Universidad de Alicante , Ap. 99, E-03080 Alicante , Spain.
This works deals with the identification of preferential site-specific activation at a model Pt surface during a multiproduct reaction. The (110)-type steps of a Pt(332) surface were selectively marked by attaching isotope-labeled CO molecules to them, and ethanol oxidation was probed by in situ Foureir transfrom infrared spectroscopy in order to precisely determine the specific sites at which CO, acetic acid, and acetaldehyde were preferentially formed. The (110) steps were active for splitting the C-C bond, but unexpectedly, we provide evidence that the pathway of CO formation was preferentially activated at (111) terraces, rather than at (110) steps.
View Article and Find Full Text PDFExperimentally Determined Site-Specific Reactivity of the Gas-Phase OH and Cl + i-Butanol Reactions Between 251 and 340 K.
J Phys Chem A
December 2016
Chemical Sciences Division, Earth System Research Laboratory, National Oceanic and Atmospheric Administration , 325 Broadway, Boulder, Colorado 80305, United States.
Product branching ratios for the gas-phase reactions of i-butanol, (CH)CHCHOH, with OH radicals (251, 294, and 340 K) and Cl atoms (294 K) were quantified in an environmental chamber study and used to interpret i-butanol site-specific reactivity. i-Butyraldehyde, acetone, acetaldehyde, and formaldehyde were observed as major stable end products in both reaction systems with carbon mass balance indistinguishable from unity. Product branching ratios for OH oxidation were found to be temperature-dependent with the α, β, and γ channels changing from 34 ± 6 to 47 ± 1%, from 58 ± 6 to 37 ± 9%, and from 8 ± 1 to 16 ± 4%, respectively, between 251 and 340 K.
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