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Parental acceptance of school-based universal depression screening for children and adolescents in primary and secondary school in China.
BMC Public Health
January 2025
Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, 81th Meishan Road, Hefei, 230032, Anhui Province, China.
Introduction: School-based universal depression screening (SBUDS) is an effective method for early identification of depression. As parents are the primary decision-makers for their children's acceptance of healthcare services, this study aims to examine rural and urban parental acceptance of SBUDS.
Methods: The study assessed parental acceptance of SBUDS for their children and its association with self-reported parental perception of depression (i.
Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults.
BMC Endocr Disord
January 2025
School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui, 230032, China.
Background: As the prevalence of metabolic syndrome (MetS) rises among older adults, the associated risks of cardiovascular diseases and diabetes significantly increase, and it is closely linked to various metabolic processes in the body. Dysregulation of tryptophan (TRP) metabolism, particularly alterations in the kynurenine (KYN) and serotonin pathways, has been linked to the onset of chronic inflammation, oxidative stress, and insulin resistance, key contributors to the development of MetS. We aim to investigate the relationship between the TRP metabolites and the risk of MetS in older adults.
View Article and Find Full Text PDFHeritable polygenic editing: the next frontier in genomic medicine?
Nature
January 2025
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that it may present. To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases.
View Article and Find Full Text PDFPreoperative radiotherapy combined with surgery versus surgery alone for primary retroperitoneal sarcoma: a meta-analysis.
Sci Rep
January 2025
Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 03080, Seoul, South Korea.
The efficacy of preoperative radiotherapy combined with surgery (preRT + S) for primary retroperitoneal sarcoma (RPS) remains unclear. This study aimed to compare preRT + S with surgery alone (SA) in patients with RPS. Core databases were searched for directly comparative studies depending on preRT.
View Article and Find Full Text PDFArtificial Intelligence, Machine Learning and Big Data in Radiation Oncology.
Hematol Oncol Clin North Am
January 2025
Division of Head and Neck/Skull Base, Department of Radiation Oncology, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, 460 West 10th Avenue, Columbus, OH 43210, USA. Electronic address:
This review explores the applications of artificial intelligence and machine learning (AI/ML) in radiation oncology, focusing on computer vision (CV) and natural language processing (NLP) techniques. We examined CV-based AI/ML in digital pathology and radiomics, highlighting the prospective clinical studies demonstrating their utility. We also reviewed NLP-based AI/ML applications in clinical documentation analysis, knowledge assessment, and quality assurance.
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