AI Article Synopsis
- The study focuses on the design and synthesis of new compounds that combine structures of melatonin and pinoline, both of which are related to serotonin.
- The researchers conducted pharmacological evaluations on these new melatonin-pinoline hybrids to assess their effects on serotonin and melatonin receptors, as well as other biological activities like antioxidant potential and blood-brain barrier permeability.
- Findings indicate that pinoline and a specific hybrid compound can promote neurogenesis and neuronal maturation in neural stem cells from adult rats, likely through their interaction with serotonin and melatonin pathways.
Article Abstract
6-Methoxy-1,2,3,4-tetrahydro-β-carboline (pinoline) and N-acetyl-5-methoxytryptamine (melatonin) are both structurally related to 5-hydroxytryptamine (serotonin). Here we describe the design, synthesis, and characterization of a series of melatonin rigid analogues resulting from the hybridization of both pinoline and melatonin structures. The pharmacological evaluation of melatonin-pinoline hybrids comprises serotonergic and melatonergic receptors, metabolic enzymes (monoamine oxidases), antioxidant potential, the in vitro blood-brain barrier permeability, and neurogenic studies. Pinoline at trace concentrations and 2-acetyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline (2) were able to stimulate early neurogenesis and neuronal maturation in an in vitro model of neural stem cells isolated from the adult rat subventricular zone. Such effects are presumably mediated via serotonergic and melatonergic stimulation, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acschemneuro.5b00041 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!