Objective: To determine the prevalence of hypodontia in the general population and orthodontic population in adolescent Chinese Hans.
Methods: Two groups named the general population (6015 subjects) and the orthodontic population (2781 subjects) were investigated, respectively. The former came from the students of three general universities in North China and the latter came from patients coming to the Department of Orthodontics, Peking University School and Hospital of Stomatology for orthodontic consulting during the summer and winter holidays in 2008. The prevalence and average missing number of hypodontic teeth was investigated in the two groups. The distribution of missing teeth was analysed between jaw positions and between genders.
Results: The prevalence of tooth agenesis was found to be 5.89% for the general population group and 7.48% for orthodontic subjects. Tooth agenesis was more frequently found in females than in males in both of the two groups and showed a statistically significant difference (P < 0.01). Tooth agenesis was found more frequently in the mandible than in the maxilla in the general population but had no difference in the orthodontic population. The prevalence and the number of missing teeth were higher in the orthodontic population than in the general population. Tooth agenesis showed different characteristics in the two populations. The congenital absence of the second mandibular premolars and the maxillary lateral incisors increased in the orthodontic population. Gender difference in hypodontia expressed an opposite effect in the two groups. Although tooth agenesis was more frequently found in females than in males, males missed more teeth than females in the orthodontic population.
Conclusion: Tooth agenesis showed different characteristics between the general and orthodontic adolescent Chinese populations.
Download full-text PDF |
Source |
---|
PLoS Genet
January 2025
Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Inositol 1,4,5-trisphosphate receptors (IP3R) mediate Ca2+ release from intracellular stores, contributing to complex regulation of numerous physiological responses. The involvement of the three IP3R genes (ITPR1, ITPR2 and ITPR3) in inherited human diseases has started to shed light on the essential roles of each receptor in different human tissues and cell types. Variants in the ITPR3 gene, which encodes IP3R3, have recently been found to cause demyelinating sensorimotor Charcot-Marie-Tooth neuropathy type 1J (CMT1J).
View Article and Find Full Text PDFPathogenic variants of GDAP1 cause Charcot-Marie-Tooth disease (CMT), an inherited neuropathy characterized by axonal degeneration. GDAP1, an atypical glutathione S-transferase, localizes to the outer mitochondrial membrane (OMM), regulating this organelle's dynamics, transport, and membrane contact sites (MCSs). It has been proposed that GDAP1 functions as a cellular redox sensor.
View Article and Find Full Text PDFAnn Clin Transl Neurol
January 2025
Institut du Cerveau et de la Moelle Épinière, ICM, Sorbonne Université, INSERM, CNRS, Paris, France.
Objective: To describe peripheral neuropathy associated with familial Creutzfeldt-Jakob disease.
Methods: We report two unrelated patients with genetic Creutzfeldt-Jakob disease with demyelinating peripheral neuropathy as initial presentation, with a comprehensive clinical, electrophysiological and neuropathological description.
Results: Both patients exhibited gait disturbance and paresthesia.
HGG Adv
January 2025
Department of Surgery, Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:
SOX9 encodes an SRY-related transcription factor critical for chondrogenesis and sex determination among other processes. Loss-of-function variants cause campomelic dysplasia and Pierre Robin Sequence, while both gain- and loss-of-function variants cause disorders of sex development. SOX9 has also been linked to scoliosis and cancers, but variants are undetermined.
View Article and Find Full Text PDFJ Morphol
January 2025
Archéozoologie, Archéobotanique: Sociétés, Pratiques et Environnements (AASPE), UMR CNRS 7209, Muséum National d'Histoire Naturelle, Paris, France.
Dental anomalies are frequent in boars and pigs, and they generally affect the first premolar loci. The prevalence of these dental anomalies was investigated in a large number of populations around the world. These studies mainly focused on the influence of domestication, size, sexual dimorphism or food hardness on these anomalies.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!