AI Article Synopsis
- The study investigated the effects of atorvastatin on preventing osteoporosis and dyslipidemia in ovariectomized rats that were fed a high-fat diet.
- Results showed that atorvastatin treatment improved bone quality and mechanical properties while preventing fat buildup in the liver and correcting lipid levels in the blood and bones.
- This research adds support to previous findings that atorvastatin could be beneficial for osteoporotic patients who also suffer from dyslipidemia.
Article Abstract
Previous studies reported that statins showed positive effects on bone in both human and animal models. This study aimed to investigate the effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in ovariectomized rats fed with high-fat emulsion. The 3-month-old female rats were subjected to either sham operations (n = 8) or ovariectomized operations (OVX, n = 24). The OVX rats were orally administered deionized water (n = 8) or standardized high-fat emulsion without (n = 8) or with atorvastatin (n = 8). All rats were injected twice with calcein before sacrificed for the purpose of double in vivo labeling. After 12 weeks, all rats were sacrificed under anesthesia. Biochemistry, histomorphometry, mechanical test, micro-computed tomography analysis, mechanical test, histology, and component analysis were performed. We found that high-fat emulsion significantly decreased body weight, bone formation, collagen content of bone, and bone biomechanics, while increased blood, liver, and bone marrow lipids. Atorvastatin treatment prevented dyslipidemia, reversed hepatic steatosis, optimized composition of bone, and improved bone mechanical properties. The current study provided further evidence that atorvastatin might be useful for the treatment of osteoporotic patients with dyslipidemia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00223-015-9975-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimization of a green tea seed oil-loaded double-layer emulsion and its preventive effects on dextran sulfate sodium-induced colitis in mice.
J Food Sci
December 2024
Joint Research Center for Food Nutrition and Health of IHM, College of Food and Nutrition, Anhui Agricultural University, Hefei, China.
Green tea seed oil (GTSO; Camellia sinensis) is rich in bioactive compounds and has great potential for preventing intestinal inflammation. Conversely, high-fat diets have been shown to promote or aggravate gastrointestinal inflammation, and the bioactive ingredients of GTSO face difficulty passing through the gastrointestinal tract while remaining intact. This study employed whey protein isolate (WPI) and sodium carboxymethyl cellulose (CMC-Na) to prepare a GTSO-loaded double-layer emulsion.
View Article and Find Full Text PDFAmelioration of tiger nut insoluble dietary fiber as a partial substitute for fat in meat emulsions: Techno-functional properties and in vitro protein digestibility.
Food Res Int
December 2024
State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China; College of Food Science, Shihezi University, Shihezi, Xinjiang 832003, China; Gulbali Institure- Agriculture Water Environment, Charles Sturt University, Wagga Wagga, NSW 2678, Australia. Electronic address:
Article Synopsis
- Tiger nut insoluble dietary fiber (TNF) at 1%-3% concentration enhances the water binding capacity and texture of low-fat meat emulsions, outperforming high-fat control samples.
- The improvements are linked to reduced fluidity of internal water in the gels and changes in the protein structure, leading to a stronger gel network.
- TNF also increases protein digestibility, indicating its potential as a fat substitute in healthier pork meat products with good quality and digestibility.
Overweight Leads to an Increase in Vitamin E Absorption and Status in Mice.
Mol Nutr Food Res
December 2024
Aix-Marseille Université, INRAE, INSERM, C2VN, Marseille, France.
Article Synopsis
- This study looks into why obese individuals may have low vitamin E (VE) levels, specifically whether it's due to issues with how VE is absorbed in the intestines.
- After 12 weeks of a high-fat diet, mice showed increased weight and fat levels compared to those on a control diet, but surprisingly, they had higher levels of α-tocopherol (a form of vitamin E) in their blood and liver.
- The results suggest that even with obesity, these mice actually absorb vitamin E more effectively rather than having impaired absorption.
Assessment of the effects of cannabidiol and a CBD-rich hemp extract in .
Front Toxicol
October 2024
Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, United States.
Consumer use of cannabidiol (CBD) is growing, but there are still data gaps regarding its possible adverse effects on reproduction and development. Multiple pathways and signaling cascades involved in organismal development and neuronal function, including endocannabinoid synthesis and signaling systems, are well conserved across phyla, suggesting that can model the effects of exogenous cannabinoids. The effects in on oxidative stress response (OxStrR), developmental timing, juvenile and adult spontaneous locomotor activity, reproductive output, and organismal CBD concentrations were assessed after exposure to purified CBD or a hemp extract suspended in 0.
View Article and Find Full Text PDFInfluence of Emulsion Lipid Droplet Crystallinity on Postprandial Endotoxin Transporters and Atherogenic And Inflammatory Profiles in Healthy Men - A Randomized Double-Blind Crossover Acute Meal Study.
Mol Nutr Food Res
November 2024
Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada.
Article Synopsis
- The study investigates how the physical state of dietary fats (liquid vs. solid) affects inflammation and endotoxin levels in healthy men after consuming high-fat meals.
- Fourteen participants consumed emulsions of palm stearin oil with different lipid states, and blood samples were taken at various times after each meal.
- The results showed no significant differences in inflammatory markers between the lipid states, although some baseline characteristics of participants influenced responses, implying that lipid crystallinity does not have a major impact on short-term inflammation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!