The purpose of this study was to investigate the in vitro dissolution performance of the different sized spray-dried nano-crystalline powders of naproxen. A DoE approach was used to formulate and optimize nano-crystalline suspensions. The critical wet milling operation parameters were i.e., drug concentration, drug-to-stabilizer ratio, stabilizer type (HPMC E15 or Tween 80) and milling intensity. The nano-crystalline suspensions were optimized for size and physical stability and then spray-dried to obtain nano-crystalline powders. Trehalose and lactose were investigated as spray-drying auxiliary excipients to achieve non-aggregating powders. Particle size, DSC and PXRD were utilized for characterization of powder formulations. A modified USP apparatus II was utilized to determine the in vitro release/dissolution of powder formulations. The size of the nano-crystalline suspensions was dependent on drug concentration and milling intensity. HPMC E15 containing formulations were better in terms of the spray-dried powder yield compared to Tween 80 containing formulations. Trehalose was selected to formulate non-aggregating nano-crystalline powders. No polymorphic changes were observed following the wet milling and spray-drying processes. Size dependent in vitro dissolution profiles, utilizing a dialysis sac method were obtained for the crystalline powders.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2015.03.047 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive modelling of laser powder bed fusion of Fe-based nanocrystalline alloys based on experimental data using multiple linear regression analysis.
Heliyon
August 2024
Department of Material Science and Engineering, University of Sheffield, Sheffield, S1 3JD, UK.
This study harnessed bivariate correlational analysis, multiple linear regression analysis and tree-based regression analysis to examine the relationship between laser process parameters and the final material properties (bulk density, saturation magnetization ( ), and coercivity ( )) of Fe-based nano-crystalline alloys fabricated via laser powder bed fusion (LPBF). A dataset comprising of 162 experimental data points served as the foundation for the investigation. Each data point encompassed five independent variables: laser power (), laser scan speed (), hatch spacing ), layer thickness (), and energy density (), along with three dependent variables: bulk density, , and .
View Article and Find Full Text PDFProbing the thermoelectric properties of aluminium-doped copper iodide.
Phys Chem Chem Phys
May 2024
Laboratory for High Performance Ceramics, Department of Metallurgical and Materials Engineering, IIT Madras, Chennai-600036, India.
Copper iodide, an environmentally friendly material abundant in nature, holds great significance for room temperature thermoelectric (TE) applications owing to its high Seebeck coefficient and optical transparency. However, to fully unlock its thermoelectric potential and match the performance of conventional TE materials, there is a need to further enhance its electrical conductivity. In this study, we have successfully synthesized nano-crystalline powders of both undoped and aluminium-doped CuI at room temperature using the chemical precipitation method in an ethanol medium.
View Article and Find Full Text PDFCalcination-based direct extraction of hydroxyapatite from bovine bone waste.
Environ Technol
December 2024
Department of Mechanical Engineering, Diponegoro University, Semarang, Indonesia.
The main chemical components of waste cow bones are apatite minerals, especially those containing calcium and phosphorus. This study investigated whether this bone could produce extracted hydroxyapatite through calcining at 900° C for different holding times (1-6 h). An average mass loss of 45% occurred in this experiment during the preparation of bone powders, which involved crushing and further calcining at this temperature.
View Article and Find Full Text PDFEnhancement of microstructural and magnetic properties of high spin Mn substituted nanocrystalline Ni-Mn-Cu-Zn ferrites.
Heliyon
February 2024
Department of Physics, Bangladesh University of Engineering & Technology, Dhaka, 1000, Bangladesh.
Mn-substituted Cu and Zn co-doped spinel-typed nano-crystalline ferrites having nominal composition NiMnCuZnFeO (x = 0.00-0.25 in 0.
View Article and Find Full Text PDFApplication of Nano-Crystalline Diamond in Tribology.
Materials (Basel)
March 2023
Chair of Functional Materials, Department of Materials Science & Engineering, Saarland University, 66123 Saarbrücken, Germany.
Nano-crystalline diamond has been extensively researched and applied in the fields of tribology, optics, quantum information and biomedicine. In virtue of its hardness, the highest in natural materials, diamond outperforms the other materials in terms of wear resistance. Compared to traditional single-crystalline and poly-crystalline diamonds, nano-crystalline diamond consists of disordered grains and thus possesses good toughness and self-sharpening.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!