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Malnutrition/exercise interaction in the rat mother-pup dyad: a behavioral and electrophysiological analysis.
Nutr Neurosci
January 2025
Department of Nutrition, Federal University of Pernambuco, Recife, Brazil.
Objectives: Maternal protein malnutrition alters brain functioning, impairing fetal development. Physical exercise during gestation benefits the fetal organism from maternal adaptive changes that may be neuroprotective. This study evaluated the effect of a low-protein diet associated with maternal voluntary physical activity (VPA) on rats' behavioral and brain electrophysiological parameters in the mother-pup dyad.
View Article and Find Full Text PDFInvestigating the Effect of Capric Acid on Antibiotic-Induced Autism-Like Behavior in Rodents.
Dev Neurobiol
January 2025
Neuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.
Article Synopsis
- The gut-brain axis is crucial in neurodevelopmental diseases, with early antibiotic use linked to autism through gut microbiota changes.
- Capric acid (CA) was studied for its potential neuroprotective effects in rodents with autism-like behaviors induced by penicillin V, highlighting the impact of gut dysbiosis.
- Results showed that CA treatment improved behavioral and biochemical changes related to autism, suggesting its potential as a treatment option for managing autism linked to gut dysbiosis.
Glycyrrhizin Attenuates White Matter Injury by Inhibiting Neuroinflammation through the HMGB1/TLR4 Pathway.
Mol Neurobiol
December 2024
Department of Pediatrics, the Second School of Medicine, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
White matter injury (WMI) is a common complication of preterm birth, potentially resulting in long-term behavioral and motor abnormalities. The objective of this study is to investigate the neuroprotective effects of glycyrrhizin (GLY) on WMI, and try to elucidate the potential mechanisms. In vivo chronic hypoxia-induced WMI mouse model and in vitro oxygen-glucose deprivation (OGD) induced WMI cell model were established, and the effects of GLY on WMI were explored through multiple assays, such as western blotting, immunofluorescence, immunohistochemistry, behavioral experiments, real-time quantitative polymerase chain reaction (RT-qPCR), transmission electron microscope (TEM), molecular docking, and bioinformatics analysis.
View Article and Find Full Text PDFTherapeutic Hypothermia and Its Role in Preserving Brain Volume in Term Neonates with Perinatal Asphyxia.
J Clin Med
November 2024
Automatics Research Group, Technologic University of Pereira, Pereira 660003, Colombia.
Perinatal asphyxia is a major cause of neonatal morbidity and mortality, often resulting in hypoxic-ischemic encephalopathy (HIE) with long-term neurodevelopmental impairments. While therapeutic hypothermia has emerged as a promising intervention to reduce brain damage, its specific impact on key brain structures and long-term neurodevelopmental outcomes remains underexplored. This study aims to evaluate the effects of therapeutic hypothermia on brain volumetry, cortical thickness, and neurodevelopment in term neonates with perinatal asphyxia.
View Article and Find Full Text PDFIntegrating Stakeholder Priorities for the Optimization of Care of the Preterm Infant in a Safety-Net NICU.
Am J Perinatol
December 2024
Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.
Objective: This study aimed to engage clinical and community stakeholders to create a prioritization matrix of interventions to reduce neonatal brain injury and improve neurodevelopmental outcomes.
Study Design: We collaborated with our community partner to establish a Lived Experience Advisory Group (LEAG). Faculty performed a literature review to identify neonatal neuroprotective interventions; additional priorities from the LEAG were also included.
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