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Alzheimers Dement
December 2024
AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Rheinland Pfalz, Germany.
Background: Parkinson's disease (PD) is a debilitating condition that affects millions of people worldwide, yet there are currently no reliable biomarkers for its diagnosis. Alpha-synuclein aggregation is a well-known hallmark of PD pathology, but the behavior and kinetics of these aggregates are poorly understood. To address this gap in knowledge, this study utilized several approaches to evaluate the potential of alpha-synuclein aggregates as potential biomarker for PD.
View Article and Find Full Text PDFBiotic factors shape the structure and dynamics of denitrifying communities within cyanobacterial aggregates.
Environ Res
January 2025
Shanghai Key Lab for Urban Ecological Processes and Eco-Restorations, School of Ecological and Environmental Sciences, East China Normal University, Shanghai, China; Center for Global Change and Ecological Forecasting, Institute of Eco-Chongming, Shanghai, China. Electronic address:
Eutrophication caused by human activities has severely impacted freshwater ecosystems, leading to harmful cyanobacterial blooms that threaten water quality and ecosystem stability. During blooms, denitrification is a key process for nitrogen removal, which can occur both in the sediment and in the waterbody mediated by cyanobacterial aggregate (CA)-associated microorganisms. In this study, the structure, dynamics and assembly mechanisms of CA-associated nirK-, nirS-, and nosZ-encoding denitrifying communities were investigated in the eutrophic Lake Taihu across the bloom season.
View Article and Find Full Text PDFDensity-dependent distributions of hosts and parasitoids resulting from density-independent dispersal rules: implications for host-parasitoid interactions and population dynamics.
Mov Ecol
December 2024
Department of Entomology, National Taiwan University, Taipei, Taiwan.
Background: The distribution of hosts and parasitoids across patches is a key factor determining the dynamics of host-parasitoid populations. To connect behavioral rules with population dynamics, it is essential to comprehend how individual-level dispersal behavior influences the distribution of individuals. Typically, a simple deterministic model has been used to describe this connection.
View Article and Find Full Text PDFHow Highly Heterogeneous Sensors with Single-Molecule Resolution can Result in Robust Continuous Monitoring Over Long Time Spans.
Adv Sci (Weinh)
December 2024
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, 5612 AZ, The Netherlands.
Biomolecular sensors with single-molecule resolution are composed of multitudes of transducers that measure state changes related to single-molecular binding and unbinding events. Conventionally, signals are aggregated from many individual transducers in order to achieve sufficient statistics. However, by aggregating signals, transducer-to-transducer differences are lost and heterogeneities cannot be studied.
View Article and Find Full Text PDFDiscrete state model of a self-aggregating colloidal system with directional interactions.
J Chem Phys
December 2024
Institute for Theoretical Physics, Technical University of Berlin, Hardenbergstr. 36, 10623 Berlin, Germany.
The construction of coarse-grained descriptions of a system's kinetics is well established in biophysics. One prominent example is Markov state models in protein folding dynamics. In this paper, we develop a coarse-grained, discrete state model of a self-aggregating colloidal particle system inspired by the concepts of Markov state modeling.
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