A rare case of clear cell variant of oral squamous cell carcinoma.

J Nat Sci Biol Med

Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Chettinad Health City Campus, Kelambakkam, Kancheepuram, Tamil Nadu, India.

Published: March 2015

AI Article Synopsis

  • Oral squamous cell carcinoma with clear cell differentiation is a rare finding, as demonstrated by a case in a 35-year-old woman with a nonhealing tongue ulcer.
  • Histopathological examination revealed lobules of malignant squamous cells with clear cell characteristics, although they tested negative for certain stains indicating a lack of mucin or glycogen.
  • Immunohistochemical analysis confirmed the presence of cytokeratin in the neoplastic cells while showing negativity for other markers, suggesting a specific profile of the tumor.

Article Abstract

Oral squamous cell carcinoma with prominent clear cell differentiation is a rare occurrence. A 35-year-old female patient presented with a nonhealing ulcer persistent for 1-month involving the left lateral border of the tongue and lingual vestibule. Lobules of malignant squamous epithelial cells with abundant cytoplasm and vesicular nuclei in the connective tissue were observed following histopathology. Neoplastic cells constituting majority of lobules exhibited clear cell changes. Periodic acid-Schiff and mucicarmine stains showed negative reaction. Immunohistochemical study using antibody for cytokeratin, revealed diffuse and intense positivity. The neoplastic cells showed complete negative reaction with antibodies for vimentin, smooth muscle actin and homatropine bromide-45 antigens.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367051PMC
http://dx.doi.org/10.4103/0976-9668.149209DOI Listing

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