AI Article Synopsis
- The study focuses on customizing treatment for acute postoperative pain based on factors that affect how patients respond to morphine.
- It involved 95 patients and found that morphine doses were influenced by age, weight, and the length of surgery, with older patients and those undergoing longer surgeries receiving lower doses.
- Genetic variations in OPRM1 and ABCB1 were also linked to morphine requirements, with certain genotypes needing significantly higher doses compared to others.
Article Abstract
Individualization of acute postoperative pain treatment on an evidence-based decision process is a major health concern. The aim of this study is to investigate the influence of genetic and non-genetic factors on the variability of response to morphine in acute postoperative pain. A group of nighty-five patients undergoing major surgery were included prospectively. At 24 h, a logistic regression model was carried out to determine the factors associated with morphine doses given by a Patient Controlled Analgesia device. The dose of morphine was associated with age (p = 0.011), patient weight (p = 0.025) and the duration of operation (p = 0.030). This dose decreased with patient's age and duration of operation and increased with patient's weight. OPRM1 and ABCB1 polymorphisms were significantly associated with administered dose of morphine (p = 0.038 and 0.012 respectively). Patients with at least one G allele for c.118A>G OPRM1 polymorphism (AG/GG) needed 4 times the dose of morphine of AA patients. Additionally, patients with ABCB1 CT and CC genotypes for c.3435C>T polymorphism were 5.6 to 7.1 times more prone to receive higher dose of morphine than TT patients. Our preliminary results support the evidence that OPRM1/ABCB1 genotypes along with age, weight and duration of operation have an impact on morphine consumption for acute postoperative pain treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394533 | PMC |
| http://dx.doi.org/10.3390/ijms16036298 | DOI Listing |
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