Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology.
Methods: DNA was provided from alcohol dependent (AD) patients (n=370) and healthy control subjects (n=168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods.
Results: We found no association between alcohol dependence and MAOA gene polymorphism.
Conclusions: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377966 | PMC |
| http://dx.doi.org/10.3390/ijerph120303317 | DOI Listing |
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