AI Article Synopsis
- The study investigates how the Foxo3 transcription factor affects lifespan extension and cancer suppression in mice under dietary restriction (DR).
- Researchers compared wild-type (WT) mice to Foxo3-knockout mice (heterozygous and homozygous) subjected to a 30% DR at 12 weeks old.
- Results show that while DR significantly extends lifespan in WT mice, it doesn’t have the same effect on Foxo3-knockout mice, indicating Foxo3 is essential for longevity but not for reducing cancer prevalence under DR.
Article Abstract
Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous ((+/-) ) and homozygous ((-/-) ) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3(+/-) or Foxo3(-/-) mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3(+/-) , and Foxo3(-/-) mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3(+/-) mice contrast with those in Foxo1(+/-) mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531086 | PMC |
| http://dx.doi.org/10.1111/acel.12340 | DOI Listing |
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