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Developmental synchrony and extraordinary multiplication rates in pathogenic organisms.

Philos Trans R Soc Lond B Biol Sci

January 2025

Department of Mathematics, Virginia Tech, Blacksburg, VA 24061, USA.

The multiplication rates of pathogenic organisms influence disease progression, efficacy of immunity and therapeutics, and potential for within-host evolution. Thus, accurate estimates of multiplication rates are essential for biological understanding. We recently showed that common methods for inferring multiplication rates from malaria infection data substantially overestimate true values (i.

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Penetration of antimicrobial treatments into the cerebrospinal fluid is essential to successfully treat infections of the central nervous system. This penetration is hindered by different barriers, including the blood-brain barrier, which is the most impermeable. However, inflammation may lead to structural alterations of these barriers, modifying their permeability.

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Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed. We present a multimodal, single-cell resolution analysis of mouse limbal cells (includes TM). In total, we sequenced 9,394 wild-type TM cell transcriptomes.

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This work reports the step-wise fabrication of a core-shell plasmonic nanocomposite Pd@BTL-Cd consisting of a BTL-Cd shell and a palladium nanoparticle core. BTL-Cd is the [Cd(BTL)·CdCl] complex where the heptadentate framework of the bis-compartmental ligand encapsulated two Cd(II) centres in separate pockets. Pd@BTL-Cd has been found to be highly efficient for the photocatalytic conversion of furfural (a biomass-derived aldehyde) to furfuryl amine reductive amination in aqueous ammonia at room temperature.

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Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers.

Cell Biosci

January 2025

Center for Reproduction and Genetics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.

Over the past two decades, the study of sperm-borne small non-coding RNAs (sncRNAs) has garnered substantial growth. Once considered mere byproducts during germ cell maturation, these sncRNAs have now been recognized as crucial carriers of epigenetic information, playing a significant role in transmitting acquired traits from paternal to offspring, particularly under environmental influences. A growing body of evidence highlights the pivotal role of these sncRNAs in facilitating epigenetic inheritance across generations.

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