Objective: The aim of this study was to compare the uptake of mail-delivered tests for colorectal cancer screening. We assessed the effect of an advance notification letter and a reminder letter, and analysed the proportion of inappropriately handled tests.
Materials And Methods: Fifteen thousand randomly selected residents of Latvia aged 50-74 years were allocated to receive one of three different test systems: either a guaiac faecal occult blood test (gFOBT) or one of two laboratory-based immunochemical tests (FIT) - FOB Gold or OC-Sensor. Half of the target population received an advance notification letter; all nonresponders were sent a reminder letter.
Results: The uptake of screening was 31.2% for the gFOBT, 44.7% for FOB Gold and 47.4% for the OC-Sensor (odds ratio 0.55; 95% confidence interval 0.51-0.60 for gFOBT vs. FOB Gold; odds ratio 0.90; 95% confidence interval 0.83-0.98 for FOB Gold vs. OC-Sensor). The uptake in the gFOBT group was improved by the advance notification letter (7.7%, P<0.0001). 30.9% returned tests were received after the reminder letter. The proportion of tests that could not be analysed because of inadequate handling was 0.9% for gFOBT, 4.4% for FOB Gold and 0.2% for the OC-Sensor (P=0.002 for gFOBT vs. OC-Sensor; P<0.001 for all comparisons vs. FOB Gold).
Conclusion: The use of FIT resulted in higher uptake. Receipt of a reminder letter was critical to participation, but the use of an advance notification letter was important mainly for gFOBT. The proportion of inappropriately handled tests was markedly higher for FOB Gold.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423577 | PMC |
| http://dx.doi.org/10.1097/MEG.0000000000000314 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Faecal immunochemical tests for patients with symptoms suggestive of colorectal cancer: An updated systematic review and multiple-threshold meta-analysis of diagnostic test accuracy studies.
Colorectal Dis
December 2024
SCHARR, University of Sheffield, Sheffield, UK.
Aim: Extending faecal immunochemical tests for haemoglobin (FIT) to all primary care patients with symptoms suggestive of colorectal cancer (CRC) could identify people who are likely to benefit from colonoscopy and facilitate earlier treatment. The aim of this work was to investigate the diagnostic accuracy of FIT across different analysers at different thresholds, as a single test or in duplicate (dual FIT).
Method: This systematic review and meta-analysis searched 10 sources (December 2022).
Stool-Based Testing for Post-Polypectomy Colorectal Cancer Surveillance Safely Reduces Colonoscopies: The MOCCAS Study.
Gastroenterology
January 2025
Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Article Synopsis
- Colonoscopy surveillance for colorectal cancer (CRC) can be burdensome for patients, and stool tests might help reduce the need for colonoscopies by identifying individuals at higher risk.
- This study involved 3453 participants aged 50-75 who completed multiple stool tests and colonoscopies to assess the accuracy of these methods for detecting advanced neoplasia.
- Results indicated that stool-based strategies could effectively reduce colonoscopy frequency by 15%-41% while being safer and more cost-effective, particularly with fecal immunochemical tests (FITs), although multitarget stool DNA testing was found to be more expensive.
Bilateral TMJ Ankylosis with limited mouth opening in pediatric patients: An anesthetic challenge.
Saudi J Anaesth
June 2024
Department of Anesthesiology, Dr B R Ambedkar Medical College and Hospital, Bengaluru, Karnataka, India.
Restricted mouth opening is a challenging airway in pediatric patients with temperomandibular joint (TMJ) ankylosis. The fiber-optic bronchoscopic nasotracheal intubation technique continues to be the gold standard for difficult airway, among the techniques available such as submandibular intubation, retrograde intubation, and tracheostomy. However, awake fiber-optic bronchoscopy (FOB) is difficult to achieve in pediatric patients.
View Article and Find Full Text PDFStable hemoglobin concentration with fecal immunochemical test at high temperatures in a Caribbean colorectal cancer screening program.
Clin Chim Acta
June 2024
Caribbean Prevention Center - Fundashon Prevenshon, Willemstad, Curaçao; Department of Clinical Pharmacology, Amsterdam University Medical Centers, Location VUMC, Amsterdam, the Netherlands; University of Curaçao, Faculty of Social and Behavioral Sciences, Willemstad, Curaçao. Electronic address:
Article Synopsis
- High temperatures negatively impact the effectiveness of fecal immunochemical tests (FIT) for detecting colorectal cancer (CRC), especially at 50°C where hemoglobin concentration (Hb) drops significantly over time.
- An experiment storing FIT samples at various temperatures revealed that samples at 30°C maintained stable Hb levels, while those at 50°C showed a rapid decrease in Hb concentration, indicating temperature plays a crucial role in test accuracy.
- Despite 80% of participants returning samples the same day and finding the collection process easy, it's advised to keep FIT samples below 30°C to ensure effectiveness, particularly in warmer climates.
Introducing Colorectal Cancer Screening in Romania - Preliminary Results from the Regional Pilot Programs (ROCCAS).
J Gastrointestin Liver Dis
March 2024
Fundeni Clinical Institute, Gastroenterology, Bucharest, Romania; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Background And Aims: Colorectal cancer (CRC) is the third cause of cancer-related death worldwide. Screening programs can reduce CRC mortality rates by up to 60%. In line with the European Union recommendations, Romania started the first four regional pilot screening programs in 2020 (the ROCCAS II projects).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!