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Objective: Intermittent claudication (IC) is a common pathology, affecting 4.5% of the UK population, and is associated with significant health burden if disease progresses to chronic limb-threatening ischaemia (CLTI). The natural history of conservatively managed IC remains poorly described, and this study aimed to examine the rate and predictors of progression from IC to CLTI.
View Article and Find Full Text PDFThe infected diabetic foot: Incidence and risk factors for dehiscence after surgery for diabetic foot infections.
Wound Repair Regen
December 2024
Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Our objective was to assess the incidence, risk factors and clinical outcomes of dehiscence after foot surgery in diabetic patients. We used pooled patient-level data from two randomised clinical trials with 240 diabetic patients who required foot surgery for infections. Most patients (n = 180, 75.
View Article and Find Full Text PDFToe-brachial index and toe systolic blood pressure for the diagnosis of peripheral arterial disease.
Cochrane Database Syst Rev
October 2024
School of Health Sciences, Western Sydney University, Campbelltown, Australia.
Background: Peripheral arterial disease (PAD) of the lower limbs is caused by atherosclerotic occlusive disease in which narrowing of arteries reduces blood flow to the lower limbs. PAD is common; it is estimated to affect 236 million individuals worldwide. Advanced age, smoking, hypertension, diabetes and concomitant cardiovascular disease are common factors associated with increased risk of PAD.
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- Research on peripheral artery disease (PAD) is hindered by the absence of a national registry and insufficient diagnostic coding in electronic health records.
- A new natural language processing (NLP) system helped establish a registry of over 103,000 new PAD patients within the Veterans Health Administration, revealing high rates of comorbidities and significant clinical outcomes over a year.
- The study found notable one-year mortality (9.4%) and incidences of cardiovascular (5.6 per 100 patient-years) and limb events (4.5 per 100 patient-years), highlighting the urgent need for better care strategies for this high-risk population.
Integrating Toe Brachial Index and longitudinal strain echocardiography for detecting coronary artery disease in patients with diabetic foot syndrome.
Int Wound J
August 2024
Healthy Heart Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Coronary artery disease (CAD) is a common problem amongst diabetic foot syndrome (DFS) patients, associated with peripheral arterial disease. This analytic cross-sectional study investigates the diagnostic efficacy of the Toe Brachial Index (TBI) in the detection of CAD in 62 DFS patients. The presence of CAD was assessed by longitudinal strain echocardiography, a sensitive method that provides a more accurate measure of intrinsic left ventricular contractility than left ventricular ejection fraction, especially in diabetic patients.
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