Upon nutrient deprivation, cells metabolize fatty acids (FAs) in mitochondria to supply energy, but how FAs, stored as triacylglycerols in lipid droplets, reach mitochondria has been mysterious. Rambold et al. (2015) now show that FA mobilization depends on triacylglycerol lipolysis, whereas autophagy feeds the lipid droplet pool for continued fueling of mitochondria.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.devcel.2015.03.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In silico analysis of non-conventional gene targets for genetic interventions to enhance fatty acid production: a review.
Mol Biol Rep
January 2025
Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS Deemed to be University, Vile Parle (West), Mumbai, 400056, India.
Since the 1990s, fatty acids (FA) have drawn significant industrial attention due to their diverse applications creating a demand for biological systems capable of producing high FA titers. While various strategies have been explored to achieve this, many of the conventional approaches rely on extensive genetic manipulations, which often result in strain instability, thus limiting its potential to yield better FA titers. Moreover, stresses such as pH, osmotic, and oxidative imbalances generated during FA production aggravate these challenges, further limiting FA titers.
View Article and Find Full Text PDFQuantitative methodology for poly (butylene adipate-co-terephthalate) (PBAT) microplastic detection in soil and compost.
Environ Sci Pollut Res Int
January 2025
Department of Packaging and Graphic Media Science, RIT, Rochester, NY, 14623, USA.
With the increasing use of biodegradable plastics in agriculture and food packaging, it has become increasingly important to assess the effects of their fragmentation and mineralization in the environment (i.e., soil, compost).
View Article and Find Full Text PDFOptimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal Diseases.
J Med Chem
January 2025
Cardio-Vascular and Metabolism, Sanofi R&D, 13 quai Jules Guesde, Vitry sur Seine 94400, France.
Peptide , a C18 fatty acid-modified single-chain relaxin analogue, was recently identified as a potent, selective, and long-lasting relaxin family peptide receptor 1 (RXFP1) agonist. Further advanced pharmacokinetic profiling of this compound highlighted elevated levels of oxidative metabolism occurring in dogs and mini pigs but only marginally in rats. This study aimed to design long-lasting relaxin analogues with increased stability against metabolic oxidation while securing subnanomolar RXFP1 potency.
View Article and Find Full Text PDFLight-Driven Carbon Fixation Using Photosynthetic Organelles in Artificial Photosynthetic Cells.
Angew Chem Int Ed Engl
January 2025
Harbin Institute of Technology, School of Chemical Engineering and Technology, No.92, West Da-Zhi Street, Harbin, 150001, China, 150001, harbin, CHINA.
Building an artificial photosynthetic cell from scratch helps to understand the working mechanisms of chloroplasts. It is a challenge to achieve carbon fixation triggered by photosynthetic organelles in an artificial cell. ATP synthase and photosystem II (PSII) are purified and reconstituted onto the phospholipid membrane to fabricate photosynthetic organelles.
View Article and Find Full Text PDFPhylogenetic and biochemical drivers of plant species variation in organic compound hydrogen stable isotopes: novel mechanistic constraints.
New Phytol
January 2025
Department of Environmental Sciences - Botany, University of Basel, Schönbeinstrasse 6, 4056, Basel, Switzerland.
Significant variation in plant organic compound hydrogen stable isotope (δH) values among species from a single location suggests species biochemistry diversity as a key driver. However, the biochemical mechanisms and the biological relevance behind this species-specific δH variation remain unclear. We analyzed δH values of cellulose and n-alkanes across 179 eudicot species in a botanical garden sampled in 2019, and cellulose, n-alkanes, fatty acids and phytol δH values from 56 eudicot species sampled in 2020.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!