A new series of cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives (i.e., MitoIr1-MitoIr7) were synthesized and developed to image mitochondria in living cells. In comparison with commercially available mitochondrial trackers, these complexes exhibit a superior capacity to selectively accumulate in mitochondria with no requirement of any membrane permeabilization or replacement of the culture medium. In addition, the excellent photostability under continuous laser irradiation as well as the stable physiological pH resistance of these complexes were confirmed by photobleaching experiments and luminescence measurements. Importantly, MitoIr7, which exhibited both excellent luminescence and high ability to locate in mitochondria, was developed to track the mitochondrial morphological changes over a long period of time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c5dt00467e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Iridium(III) Blue Phosphors with Heteroleptic Carbene Cyclometalates: Isomerization, Emission Tuning, and OLED Fabrications.
Angew Chem Int Ed Engl
January 2025
City University of Hong Kong, Materials Sciences and Engineering, 83 Tat Chee Road, Kowloon, 999077, Kowloon Tong, HONG KONG.
Ir(III) complexes are particularly noted for their excellent photophysical properties in giving blue OLED phosphors. In this study, two distinctive carbene pro-chelates LAH2+ and LBH2+ (or LCH2+) were employed in preparation of heteroleptic Ir(III) complexes, to which LAH2+ bears a cyano substituted benzoimidazolium along with N-mesityl appendage, while LBH2+ (or LCH2+) carries the symmetrical benzoimidazolium entity. Notably, the reversible equilibration at high temperature was observed for m, f-ct14 and m, f-ct15 with a single LA chelate.
View Article and Find Full Text PDFLabel-free 3D cell imaging using hydrogels functionalized with switchable iridium complexes.
Chemistry
January 2025
Istituto di Ricerche Farmacologiche Mario Negri, Laboratory of Biochemistry and Protein Chemistry, Via Mario Negri, 2, 20156, Milano, ITALY.
The use of fluorescent labels is the most common tool to visualize cells. However, the internalization of dye molecules often modifies the cell behavior. In this paper we demonstrate that it is possible to transiently label cells using a 3D scaffold, a hydrogel, covalently functionalized with luminescent cyclometalated iridium(III) complexes.
View Article and Find Full Text PDFTriphenylphosphine-modified cyclometalated iridium complexes as mitochondria-targeting anticancer agents with enhanced selectivity.
Bioorg Chem
February 2025
Key Laboratory of Life-Organic Analysis of Shandong Province, Key Laboratory of Green Natural Products and Pharmaceutical Intermediates in Colleges and Universities of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165 PR China. Electronic address:
This study presents the development and evaluation of triphenylphosphine-modified cyclometalated iridium complexes as selective anticancer agents targeting mitochondria. By leveraging the mitochondrial localization capability of the triphenylphosphine group, these complexes displayed promising cytotoxicity in the micromolar range (3.12-7.
View Article and Find Full Text PDFpH- and Saccharide-Responsive Cyclometalated Iridium(III) Complexes with Boronic Acid Moieties Displaying a Wide Range of Phosphorescence Colors.
Chemistry
December 2024
Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
Single compounds displaying a wide range of luminescent colors are attractive optical materials for sensor applications. In this study, we present the beneficial combination of a cyclometalated iridium(III) complex scaffold and boronic acid units for designing stimulus-responsive luminescent materials with various emission colors. Five iridium(III) complexes bearing a diboronic acid ligand (bpyB2) were synthesized: Ir(C^N)bpyB2 (C^N=2-phenylpyridine (1), 2-(2,4-difluorophenyl)pyridine (2), 2-(4-methoxyphenyl)pyridine (3), benzo[h]quinoline (4), 1-phenylisoquinoline (5)).
View Article and Find Full Text PDFEffect of the Appended Morpholinyl Group on Photophysical Behavior of Mono- and Bis-cyclometalated Terpyridine Iridium(III) Chromophores.
Inorg Chem
January 2025
Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland.
This paper provides extensive studies of [IrCl(Ph-py)(morph-CH-terpy-κN)]PF (), [Ir(Ph-py)(morph-CH-terpy-κN)]PF (), [IrCl(Ph-py)(Ph-terpy-κN)]PF (), and [Ir(Ph-py)(Ph-terpy-κN)]PF () designed to demonstrate the possibility of controlling the photophysical properties of mono- and bis-cyclometalated complexes [IrCl(Ph-py)(R-CH-terpy-κN)]PF and [Ir(Ph-py)(R-CH-terpy-κN)]PF through a remote electron-donating substituent introduced into the 4'-position of 2,2':6',2″-terpyridine (terpy) via the phenyl linker. The attachment of the morpholinyl (morph) group was evidenced to induce dramatic changes in the emission characteristics of the monocyclometalated Ir(III) systems with coordinated R-CH-terpy ligand (κN). In solution, the obtained complex [IrCl(Ph-py)(morph-CH-terpy-κN)]PF was found to be a rare example of dual-emissive Ir(III) systems.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!