Background: Lithium, which is often used for the treatment of bipolar disorders, is mainly recovered into urine after being orally administered. Due to the fact that it is completely absorbed via the gastrointestinal tract, it remains unknown whether biliary excretion is involved in the lithium disposition. In this study, we examined biliary excretion of lithium in rats and compared these with renal excretion.
Materials And Methods: After the injection of lithium chloride to femoral vein, plasma levels and excretion into urine and bile of lithium were evaluated.
Results: After its intravenous administration as a bolus, the plasma concentration of lithium decreased time-dependently. Until 60 min, 6.47% and 0.694% of injected lithium were excreted into urine and bile, respectively. The biliary clearance of lithium was calculated to be 0.0779 mL/min/kg, and this was 11.3% of the renal clearance.
Conclusions: These findings suggest the low ability of the liver to eliminate lithium from plasma in comparison with the kidney in rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1515/dmdi-2014-0033 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Resistance-Associated Substitutions (RAS) and Clinical Factors as Determinants of Sofosbuvir-Daclatasvir Treatment Outcomes in Chronic Hepatitis C Patients.
Acta Med Indones
October 2024
Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia..
Background: Direct acting antivirals (DAAs) have demonstrated remarkable efficacy, in achieving hepatitis C viral (HCV) elimination rates higher than 90%. One particular concern associated with treatment failure is the emergence of resistance associated substitutions (RASs) in the genome. The occurrence of RASs highlights the adaptability and resilience of the HCV.
View Article and Find Full Text PDFIndocyanine green faecal excretion holds potential for diagnosis of neonatal biliary atresia.
Clin Exp Hepatol
March 2024
Pediatric Surgery, Nagoya City University Midori Municipal Hospital, Japan.
Aim Of The Study: This study aimed to establish an objective, simple, and minimally invasive screening method to detect patients with biliary atresia during neonatal checkups by using indocyanine green (ICG) fluorescence in the stool.
Material And Methods: We produced a rat model of extrahepatic biliary obstruction (group O, = 9) and compared the stools from these rats with those of control group rats (group C, = 6) by a fluorescence technique. ICG was administered (0.
Polymeric Anti-Antibiotic Microparticles to Prevent Antibiotic Resistance Evolution.
Small
January 2025
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Vancomycin (VAN) and daptomycin (DAP) are among the last-resort antibiotics for treating multidrug-resistant Gram-positive bacterial infections. They are administered intravenously (IV); however, ≈5 - 10% of the total IV dose is released in the gastrointestinal (GI) tract via biliary excretion, driving resistance emergence in commensal Enterococcus faecium (E. faecium) populations.
View Article and Find Full Text PDFHepatitis C virus-free endoscope procedures project: An in-hospital elimination approach.
Kaohsiung J Med Sci
January 2025
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Hepatitis C virus (HCV) elimination in the care cascades for patients receiving invasive procedures remains elusive. This study aimed to evaluate the efficacy of HCV-free Endoscope Procedures Project (CEPP) in the effort toward hospital HCV micro-elimination in Taiwan. An electronic medical record (EMR)-based remind system was introduced into gastrointestinal, surgical, urological, and gynecological departments prior to the endoscopy procedures.
View Article and Find Full Text PDFHuman liver cell-based assays for the prediction of hepatic bile acid efflux transporter inhibition by drugs.
Expert Opin Drug Metab Toxicol
January 2025
Institut de R&D Servier, Paris-Saclay Gif-sur-Yvette, France.
Introduction: Drug-mediated inhibition of bile salt efflux transporters may cause liver injury. In vitro prediction of drug effects toward canalicular and/or sinusoidal efflux of bile salts from human hepatocytes is therefore a major issue, which can be addressed using liver cell-based assays.
Area Covered: This review, based on a thorough literature search in the scientific databases PubMed and Web of Science, provides key information about hepatic transporters implicated in bile salt efflux, the human liver cell models available for investigating functional inhibition of bile salt efflux, the different methodologies used for this purpose, and the modes of expression of the results.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!