RNA X DNA in situ hybridization revealed a high level of ETn ("early transposon") transcripts in the pluripotent cell lineage of the 3.5- to 7.5-day mouse embryo. Some extra-embryonic ectoderm derivatives also show a high level of ETn transcripts at these stages. Older embryos (8.5 days and later) have a uniform low level of ETn transcripts.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC397490 | PMC |
| http://dx.doi.org/10.1073/pnas.82.7.2054 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The relationship between drug-induced immunogenicity and hypersensitivity reactions and skin tests related to infliximab, etanercept and adalimumab in patients with rheumatoid arthritis and ankylosing spondylitis.
Turk J Med Sci
December 2024
Division of Clinical Immunology and Allergy, Department of Chest Diseases, Faculty of Medicine, Ankara University, Ankara, Turkiye.
Article Synopsis
- The study aimed to explore the connection between serum antidrug antibodies (ADAbs), hypersensitivity reactions, and local injection site reactions in patients with ankylosing spondylitis and rheumatoid arthritis who were on anti-TNF treatments.
- Sixty-nine patients with ankylosing spondylitis and 46 with rheumatoid arthritis were evaluated, measuring their drug levels, disease activity scores, and conducting skin tests to assess hypersensitivity.
- Results indicated a significant link between hypersensitivity reactions (both immediate and local) and the intradermal tests in patients taking anti-TNF drugs, particularly with adalimumab and etanercept.
Uncovering multiscale structure in the variability of larval zebrafish navigation.
Proc Natl Acad Sci U S A
November 2024
Sorbonne University, Paris Brain Institute (Institut du Cerveau), Inserm U1127, CNRS UMR 7225, Paris 75013, France.
Article Synopsis
- Animals exhibit varied movement strategies based on their internal states and environmental cues, leading to a structured analysis of these behaviors.
- Markov models are utilized to analyze movement sequences, allowing for a comparative study of behaviors among individual larval zebrafish.
- The research finds that fish adapt their movement based on sensory stimuli—cruising in light and wandering when searching for food or reacting to threats—while revealing hidden states that influence decision-making beyond what the stimuli alone can explain.
Inhibition of hepatitis B virus through PPAR-JAK/STAT pathway modulation by electroacupuncture and tenofovir disoproxil fumarate combination therapy.
Int Immunopharmacol
December 2024
College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400010, China; College of Acupuncture and Tuina, Chongqing College of Traditional Chinese Medicine, Chongqing 402760, China. Electronic address:
Background: Acupuncture combined with nucleos(t)ide analogues (NAs) has shown promise in treating chronic hepatitis B (CHB), though mechanisms remain unclear. This study evaluates the antiviral effects of combining acupuncture with NAs against hepatitis B virus (HBV) and explores underlying mechanisms.
Methods: The HBV-infected mouse model, established using the high-pressure hydrodynamic method, was divided into three groups: normal saline (NS), tenofovir disoproxil fumarate (TF), and electroacupuncture combined with TF (E_T), n = 6.
Reconstruction of bone defects around the ankle with retrograde gentamicin-coated tibial intramedullary nail (ETN PROtect™) for tibiotalocalcaneal arthrodesis: a case series.
Eur J Orthop Surg Traumatol
October 2024
Limb of Lengthening and Reconstruction Unit, Clínica Imbanaco Grupo QuirónSalud, Carrera 38A #5ª-100, Tower A, Office 803, Cali, Colombia.
Article Synopsis
- The study aimed to evaluate the effectiveness of a gentamicin-coated tibial nail (PROtect™) in patients needing tibiotalocalcaneal arthrodesis due to tibial defects.
- It involved a review of seven male patients treated between January 2018 and December 2023, focusing on fracture healing, complications, and quality of life outcomes.
- Results showed that most patients achieved fracture union, though a few experienced complications; overall, PROtect™ was deemed a promising option for enhancing bone healing and reducing infection risks in complex cases.
The emerging role of ethanolamine phosphate phospholyase in regulating hepatic phosphatidylethanolamine and plasma lipoprotein metabolism in mice.
FASEB J
September 2024
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Ethanolamine phosphate phospholyase (ETNPPL) is an enzyme that irreversibly degrades phospho-ethanolamine (p-ETN), an intermediate in the Kennedy pathway of phosphatidylethanolamine (PE) biosynthesis. PE is the second most abundant phospholipid in mammalian membranes. Disturbance of hepatic phospholipid homeostasis has been linked to the development of metabolic dysfunction-associated steatotic liver disease (MASLD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!