AI Article Synopsis
- The study investigates the connection between lactate acidosis and mitochondrial insufficiency in pediatric neurological syndromes.
- It involved 200 patients with various neurodevelopmental disorders, revealing that 27% experienced lactate acidosis, while 8% showed mitochondrial insufficiency.
- The findings highlight the need for tailored treatment strategies to manage energy and oxidative metabolism in patients with neurological symptoms.
Article Abstract
The aim of the study was to detect the role of lactate acidosis, also to find the share of mitochondrial insufficiency in development of various neurologic syndromes in children and adolescents. The detection of cellular energetic metabolism and acid based imbalance is also important for finding the specific method of management. We have studied 200 patients with various degree of neurodevelopment delay with epilepsy and epileptic syndromes, headache, vertigo, early strokes, floppy infant syndrome, atrophy of ophthalmic nerve, cataracta, neurosensory deafness, systemic myopathy, cerebral palsy. In 27% of cases with various ages we have detected lactate acidosis and increase level of pyruvate. Mitochondrial insufficiency was seen in 8% of cases which gives us opportunity to find the specific method of treatment in this group of patients. Each patient with neurological symptoms requires correction of parameters of energetic and oxidative metabolism.
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