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Destructive effects of UVC radiation on Drosophila melanogaster: Mortality, fertility, mutations, and molecular mechanisms.
PLoS One
May 2024
Biology Department, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.
The detrimental effects of ultraviolet C (UVC) radiation on living organisms, with a specific focus on the fruit fly Drosophila melanogaster, were examined. This study investigated the impact of heightened UVC radiation exposure on D. melanogaster by assessing mortality and fertility rates, studying phenotypic mutations, and investigating the associated molecular mechanisms.
View Article and Find Full Text PDFThe Jinggangmycin-induced Mthl2 gene regulates the development and stress resistance in Nilaparvata lugens Stål (Hemiptera: Delphacidae).
Pestic Biochem Physiol
November 2023
Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, PR China. Electronic address:
Methuselah (Mth) belongs to the GPCR family B, which regulates various biological processes and stress responses. The previous transcriptome data showed jinggangmycin (JGM)-induced Mthl2 expression. However, its detailed functional role remained unclear in brown planthopper, Nilaparvata lugens Stål.
View Article and Find Full Text PDF, a potential homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies.
Proc Natl Acad Sci U S A
July 2023
Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China.
Injection of OCs into adult male flies induces a strong transcriptomic response in the host flies featuring in particular genes encoding bona fide G coupled proteins, among which the gene for is prominent. The injection is followed after a 3-d lag period, by the proliferation of the oncogenic cells. We hypothesized that through the product of the host might control, at least in part, this proliferation as a defense reaction.
View Article and Find Full Text PDFExtension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging.
Exp Biol Med (Maywood)
April 2023
V. N. Karazin Kharkiv National University, Kharkiv 61022, Ukraine.
The end products of catabolism of tryptophan (Trp), an essential amino acid, are known to affect mechanism(s) of aging, a neurodegenerative condition. This review focuses on the possible role of the initial step of Trp catabolism, kynurenine (Kyn) formation from Trp, in aging mechanism(s). Rate-limiting enzymes of Trp conversion into Kyn are tryptophan 2,3-dioxygenase 2 (TDO) or indoleamine 2,3-dioxygenase (IDO).
View Article and Find Full Text PDFReal-world evidence on atopic dermatitis: Baseline characteristics and predictors of treatment choice in the TARGET cohort.
J Am Acad Dermatol
August 2023
Northwestern Feinberg School of Medicine, NMH/Arkes Family Pavilion, Chicago, Illinois.
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