It is wonderful to be able to record the establishment and growth of a professional journal after thirty-five years, and to celebrate the splendid career of Abba J. Kastin as an editor as well as a scientist and educator. Abba is also an enriched human being who is both sophisticated and simple, and we are proud to be life-long friends of his. This Festschrift reviews how we (the Olsons) started our careers as neuropsychologists, our interactions with Abba, reflection of the job as neuroscientists, and discussion of the growth and future of Peptides with the new publishing fads.
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| http://dx.doi.org/10.1016/j.peptides.2015.03.008 | DOI Listing |
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Front Psychiatry
March 2022
Beijing Key Laboratory of Mental Disorders, The National Clinical Research Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Our previous studies documented that interleukin-15 receptor α (IL-15Rα) knockout (KO) mice exhibited hyperactivity, memory impairment, and desperate behavior, which are core features of schizophrenia and depression. Due to the overlapping symptomology and pathogenesis observed for schizophrenia and depression, the present study attempted to determine whether IL-15Rα was associated with the risk of schizophrenia or depression. One hundred fifty-six participants, including 63 schizophrenia patients, 29 depressive patients, and 64 age-matched healthy controls, were enrolled in the study.
View Article and Find Full Text PDFPhenotypic Resemblance to Neuropsychiatric Disorder and Altered mRNA Profiles in Cortex and Hippocampus Underlying α Knockout.
Front Neurosci
February 2021
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Previous studies of the functions of α have been limited to immune activities and skeletal muscle development. Immunological factors have been identified as one of the multiple causes of psychosis, and neurological symptoms have been described in α knockout (KO) mice. Seeking to explore possible mechanisms for this in the α mouse brain, we analyzed gene expression patterns in the cortex and hippocampus using the RNA-seq technique.
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The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Background: Schizophrenia is a complex and debilitating mental disorder with strong heritability. Its pathogenesis involves immune dysregulation. Interleukin 15 and interleukin 15 receptor alpha(IL-15Rα) are classical immune molecules.
View Article and Find Full Text PDFThe Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.
Sci Rep
February 2019
Department of Chemistry, University of Otago, Dunedin, New Zealand.
Brain aging and Alzheimer's disease both demonstrate the accumulation of beta-amyloid protein containing "plaques" and tau protein containing "tangles" that contribute to accelerated memory loss and cognitive decline. In the present investigation we identified a specific plant extract and its constituents as a potential alternative natural solution for preventing and reducing both brain "plaques and tangles". PTI-00703 cat's claw (Uncaria tomentosa from a specific Peruvian source), a specific and natural plant extract from the Amazon rain forest, was identified as a potent inhibitor and reducer of both beta-amyloid fibrils (the main component of "plaques") and tau protein paired helical filaments/fibrils (the main component of "tangles").
View Article and Find Full Text PDFSpinal Cord Injury Changes Cytokine Transport.
CNS Neurol Disord Drug Targets
October 2017
Biopotentials Sleep Center, 8032 Summa Avenue, Suite A, Baton Rouge, LA 70809, USA.
Here we summarize three aspects of our understanding of the interactions of cytokines and neurotrophic peptides/proteins with the blood-brain and bloodspinal cord barriers (BBB): (a) pharmacokinetic analysis that has been reported for native cytokines and neurotrophic peptides/proteins; (b) landmark work on conjugated proteins to enhance their delivery across the normal BBB; and (c) regulatory changes under pathophysiological conditions in rodents, particularly after spinal cord injury (SCI). First, though the BBB restricts the permeation of large proteins, some cytokines and neurotrophic peptides/proteins in the periphery can reach the central nervous system (CNS) by specific transport systems. Moreover, SCI and some other disease processes may regulate these transport systems.
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