Purpose: Explore whether agent-based modeling and simulation can help healthcare administrators discover interventions that increase population wellness and quality of care while, simultaneously, decreasing costs. Since important dynamics often lie in the social determinants outside the health facilities that provide services, this study thus models the problem at three levels (individuals, organizations, and society).
Methods: The study explores the utility of translating an existing (prize winning) software for modeling complex societal systems and agent's daily life activities (like a Sim City style of software), into a desired decision support system. A case study tests if the 3 levels of system modeling approach is feasible, valid, and useful. The case study involves an urban population with serious mental health and Philadelphia's Medicaid population (n=527,056), in particular.
Results: Section 3 explains the models using data from the case study and thereby establishes feasibility of the approach for modeling a real system. The models were trained and tuned using national epidemiologic datasets and various domain expert inputs. To avoid co-mingling of training and testing data, the simulations were then run and compared (Section 4.1) to an analysis of 250,000 Philadelphia patient hospital admissions for the year 2010 in terms of re-hospitalization rate, number of doctor visits, and days in hospital. Based on the Student t-test, deviations between simulated vs. real world outcomes are not statistically significant. Validity is thus established for the 2008-2010 timeframe. We computed models of various types of interventions that were ineffective as well as 4 categories of interventions (e.g., reduced per-nurse caseload, increased check-ins and stays, etc.) that result in improvement in well-being and cost.
Conclusions: The 3 level approach appears to be useful to help health administrators sort through system complexities to find effective interventions at lower costs.
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http://dx.doi.org/10.1016/j.artmed.2014.08.006 | DOI Listing |
ACS Biomater Sci Eng
January 2025
Advanced Materials Department, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.
Characterization and formation of the biomineral aragonite structures of the Noah's Ark shell ( L.,1758) were studied from structural, morphogenetic, and biochemical points of view. Structural and morphological features were examined using X-ray diffraction, field-emission scanning electron microscopy, and atomic force microscopy, while thermal properties were determined by thermogravimetric and differential thermal analyses.
View Article and Find Full Text PDFN Engl J Med
January 2025
From the Departments of Medicine (D.R.) and Radiology (S.S.), Massachusetts General Hospital, the Departments of Medicine (D.R., S.D., J.A.S.) and Radiology (S.S.), Harvard Medical School, and the Department of Medicine, Brigham and Women's Hospital (S.D., J.A.S.) - all in Boston.
N Engl J Med
January 2025
Baylor College of Medicine, Houston, TX
Rev Soc Bras Med Trop
January 2025
Universidade Federal do Paraná, Departamento de Clínica Médica, Programa de pós-graduação em Medicina Interna e Ciências da Saúde, Curitiba, PR, Brasil.
Cryptococcal disease is the third most common invasive fungal infection in solid organ transplant recipients and is associated with high-morbidity and -mortality rates. Donor-derived Cryptococcus spp. infection typically manifests within the first month post-procedure and has historically been caused by C.
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