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Evidence That Growth Mixture Model Results Are Highly Sensitive to Scoring Decisions.
Multivariate Behav Res
January 2025
Wake Forest University, Winston-Salem, NC, USA.
Interest in identifying latent growth profiles to support the psychological and social-emotional development of individuals has translated into the widespread use of growth mixture models (GMMs). In most cases, GMMs are based on scores from item responses collected using survey scales or other measures. Research already shows that GMMs can be sensitive to departures from ideal modeling conditions and that growth model results outside of GMMs are sensitive to decisions about how item responses are scored, but the impact of scoring decisions on GMMs has never been investigated.
View Article and Find Full Text PDFDoes Generalization Occur Following Speech Therapy? A Study in Children With a Cleft Palate.
J Speech Lang Hear Res
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong.
Purpose: This study compared the occurrence of different types of generalization (within-class, across-class, and total generalization) following motor-phonetic speech therapy and linguistic-phonological speech therapy in children with a cleft palate ± cleft lip (CP ± L).
Method: Thirteen children with a CP ± L ( = 7.50 years) who previously participated in a block-randomized, sham-controlled design comparing motor-phonetic therapy ( = 7) and linguistic-phonological therapy ( = 6) participated in this study.
Mapping the cell therapy landscape: insights into clinical trials and regulatory advances in China.
J Hematol Oncol
October 2024
Vanke School of Public Health, Tsinghua University, Beijing, China.
Article Synopsis
- * China's dual-track regulatory framework has led to it becoming the second largest nation for cell therapy clinical trials, with a significant focus on hematologic malignancies despite a high demand for treatments for solid tumors.
- * The study reveals that over 90% of cell therapy trials in China are investigator-initiated, highlighting the need for stricter regulations and guidelines to minimize redundant research and promote value-driven product development.
Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes.
Front Immunol
October 2024
School of Laboratory Medicine, Medical Science, University of KwaZulu-Natal, Durban, South Africa.
Variation within the non-coding genome may influence the regulation and expression of important genes involved in immune control such as the human leukocyte antigen (HLA) system. Class I and Class II HLA molecules are essential for peptide presentation which is required for T lymphocyte activation. Single nucleotide polymorphisms within non-coding regions of HLA Class I and Class II genes may influence the expression of these genes by affecting the binding of transcription factors and chromatin modeling molecules.
View Article and Find Full Text PDFAcidocin A and Acidocin 8912 Belong to a Distinct Subfamily of Class II Bacteriocins with a Broad Spectrum of Antimicrobial Activity.
Int J Mol Sci
September 2024
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Within class II bacteriocins, we assume the presence of a separate subfamily of antimicrobial peptides possessing a broad spectrum of antimicrobial activity. Although these peptides are structurally related to the subclass IIa (pediocin-like) bacteriocins, they have significant differences in biological activities and, probably, a mechanism of their antimicrobial action. A representative of this subfamily is acidocin A from TK9201.
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